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Peli1 pellino 1 [ Mus musculus (house mouse) ]

Gene ID: 67245, updated on 13-Dec-2022

Summary

Official Symbol
Peli1provided by MGI
Official Full Name
pellino 1provided by MGI
Primary source
MGI:MGI:1914495
See related
Ensembl:ENSMUSG00000020134 AllianceGenome:MGI:1914495
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D11Ertd676e; 2810468L03Rik; A930031K15Rik
Summary
Enables ubiquitin protein ligase activity. Involved in negative regulation of necroptotic process. Acts upstream of or within several processes, including positive regulation of macromolecule metabolic process; positive regulation of signal transduction; and regulation of lymphocyte proliferation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skin. Orthologous to human PELI1 (pellino E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 20.6), whole brain E14.5 (RPKM 20.6) and 28 other tissues See more
Orthologs
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Genomic context

See Peli1 in Genome Data Viewer
Location:
11 A3.1; 11 13.81 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (21041283..21100327)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (21091283..21150327)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39608 Neighboring gene predicted gene, 46273 Neighboring gene predicted gene, 32293 Neighboring gene ATP synthase subunit g, mitochondrial pseudogene Neighboring gene predicted gene 12040 Neighboring gene ribosomal protein, large, P0 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of necroptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of necroptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of B cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of toll-like receptor 3 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of toll-like receptor 4 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K48-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein polyubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of Toll signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to dsRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase pellino homolog 1
Names
RING-type E3 ubiquitin transferase pellino homolog 1
protein pellino homolog 1
NP_075813.2
XP_011242048.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023324.2NP_075813.2  E3 ubiquitin-protein ligase pellino homolog 1

    See identical proteins and their annotated locations for NP_075813.2

    Status: VALIDATED

    Source sequence(s)
    AK152900, AL669979, AW124934
    Consensus CDS
    CCDS24462.1
    UniProtKB/Swiss-Prot
    Q8C669, Q9ERJ8
    UniProtKB/TrEMBL
    Q5SRW7
    Related
    ENSMUSP00000090979.6, ENSMUST00000093290.12
    Conserved Domains (1) summary
    pfam04710
    Location:10418
    Pellino; Pellino

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    21041283..21100327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243746.2XP_011242048.1  E3 ubiquitin-protein ligase pellino homolog 1 isoform X1

    Conserved Domains (1) summary
    pfam04710
    Location:10352
    Pellino