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Srfbp1 serum response factor binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 67222, updated on 5-Mar-2024

Summary

Official Symbol
Srfbp1provided by MGI
Official Full Name
serum response factor binding protein 1provided by MGI
Primary source
MGI:MGI:1914472
See related
Ensembl:ENSMUSG00000024528 AllianceGenome:MGI:1914472
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p49/STRAP; 2810036K01Rik
Summary
Predicted to be involved in maturation of SSU-rRNA. Located in nucleus. Is expressed in several structures, including axial musculature; genitourinary system; neural ectoderm; orbito-sphenoid; and submandibular gland primordium. Orthologous to human SRFBP1 (serum response factor binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 7.6), placenta adult (RPKM 5.3) and 21 other tissues See more
Orthologs
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Genomic context

See Srfbp1 in Genome Data Viewer
Location:
18 D1; 18 28.21 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (52598703..52625005)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (52465631..52491933)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44599 Neighboring gene predicted gene, 22259 Neighboring gene STARR-seq mESC enhancer starr_44600 Neighboring gene ferritin mitochondrial Neighboring gene STARR-seq mESC enhancer starr_44601 Neighboring gene STARR-positive B cell enhancer ABC_E7585 Neighboring gene STARR-seq mESC enhancer starr_44602 Neighboring gene ribosomal protein S3A pseudogene Neighboring gene lysyl oxidase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of 90S preribosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serum response factor-binding protein 1
Names
SRF-dependent transcription regulation associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026040.4NP_080316.3  serum response factor-binding protein 1

    See identical proteins and their annotated locations for NP_080316.3

    Status: VALIDATED

    Source sequence(s)
    AC109203
    Consensus CDS
    CCDS37819.1
    UniProtKB/Swiss-Prot
    Q3UGY0, Q3UMK2, Q3UR20, Q8R3W6, Q9CRL0, Q9CZ91
    Related
    ENSMUSP00000025406.8, ENSMUST00000025406.9
    Conserved Domains (1) summary
    pfam09073
    Location:411440
    BUD22; BUD22

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    52598703..52625005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_386008.4 RNA Sequence