U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Plekho1 pleckstrin homology domain containing, family O member 1 [ Mus musculus (house mouse) ]

Gene ID: 67220, updated on 13-Dec-2022

Summary

Official Symbol
Plekho1provided by MGI
Official Full Name
pleckstrin homology domain containing, family O member 1provided by MGI
Primary source
MGI:MGI:1914470
See related
Ensembl:ENSMUSG00000015745 AllianceGenome:MGI:1914470
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Jza2; Ckip1; CKIP-1; JZA-20; 2810052M02Rik
Summary
Acts upstream of or within several processes, including lamellipodium morphogenesis; myoblast fusion; and myoblast migration. Located in muscle cell projection membrane and ruffle membrane. Orthologous to human PLEKHO1 (pleckstrin homology domain containing O1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 51.0), CNS E11.5 (RPKM 47.2) and 27 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Plekho1 in Genome Data Viewer
Location:
3; 3 F2.1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95896121..95903300, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95988809..95999355, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ferritin light chain 2 pseudogene Neighboring gene predicted gene 9054 Neighboring gene vacuolar protein sorting 45 Neighboring gene predicted gene, 54210 Neighboring gene predicted gene, 30044

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC151380

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in muscle cell projection membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in muscle cell projection membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in ruffle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in ruffle membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
pleckstrin homology domain-containing family O member 1
Names
CK2 interacting protein 1
Jun zipper-associated 2
PH domain-containing family O member 1
TNF intracellular domain-interacting protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023320.2NP_075809.1  pleckstrin homology domain-containing family O member 1

    See identical proteins and their annotated locations for NP_075809.1

    Status: PROVISIONAL

    Source sequence(s)
    AC092855
    Consensus CDS
    CCDS17627.1
    UniProtKB/Swiss-Prot
    Q9CXH2, Q9JIY0
    Related
    ENSMUSP00000015889.4, ENSMUST00000015889.10
    Conserved Domains (2) summary
    cd13317
    Location:17126
    PH_PLEKHO1_PLEKHO2; Pleckstrin homology domain-containing family O Pleckstrin homology domain
    pfam00169
    Location:25130
    PH; PH domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    95896121..95903300 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501930.4XP_006501993.1  pleckstrin homology domain-containing family O member 1 isoform X1

    Conserved Domains (1) summary
    cd13317
    Location:10118
    PH_PLEKHO1_PLEKHO2; Pleckstrin homology domain-containing family O Pleckstrin homology domain
  2. XM_011240206.2XP_011238508.1  pleckstrin homology domain-containing family O member 1 isoform X2