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SRF serum response factor [ Homo sapiens (human) ]

Gene ID: 6722, updated on 5-Aug-2022

Summary

Official Symbol
SRFprovided by HGNC
Official Full Name
serum response factorprovided by HGNC
Primary source
HGNC:HGNC:11291
See related
Ensembl:ENSG00000112658 MIM:600589; AllianceGenome:HGNC:11291
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCM1
Summary
This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
Expression
Ubiquitous expression in prostate (RPKM 20.2), heart (RPKM 19.8) and 25 other tissues See more
Orthologs
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Genomic context

See SRF in Genome Data Viewer
Location:
6p21.1
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (43171269..43181506)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (43000031..43010279)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43139007..43149244)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene kinesin light chain 4 Neighboring gene KLC4 antisense RNA 1 Neighboring gene protein tyrosine kinase 7 (inactive) Neighboring gene cullin 9 Neighboring gene 2'-deoxynucleoside 5'-phosphate N-hydrolase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env The interaction of the long cytoplasmic tail of HIV-1 gp41 with the carboxy-terminal regulatory domain of p115-RhoGEF inhibits p115-mediated actin stress fiber formation and activation of serum response factor (SRF) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IGI
Inferred from Genetic Interaction
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables histone deacetylase binding IEA
Inferred from Electronic Annotation
more info
 
enables primary miRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables serum response element binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables serum response element binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in angiogenesis involved in wound healing TAS
Traceable Author Statement
more info
PubMed 
involved_in associative learning IEA
Inferred from Electronic Annotation
more info
 
involved_in axon extension IEA
Inferred from Electronic Annotation
more info
 
involved_in bicellular tight junction assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in branching involved in blood vessel morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in bronchus cartilage development IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac muscle cell myoblast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cardiac myofibril assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac vascular smooth muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular senescence IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dorsal aorta morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial structure maintenance IEA
Inferred from Electronic Annotation
more info
 
involved_in erythrocyte development IEA
Inferred from Electronic Annotation
more info
 
involved_in eyelid development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
involved_in face development IEA
Inferred from Electronic Annotation
more info
 
involved_in filopodium assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in heart looping ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in heart trabecula formation IEA
Inferred from Electronic Annotation
more info
 
involved_in hematopoietic stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in hippocampus development IEA
Inferred from Electronic Annotation
more info
 
involved_in long-term memory IEA
Inferred from Electronic Annotation
more info
 
involved_in long-term synaptic depression IEA
Inferred from Electronic Annotation
more info
 
involved_in lung morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in lung smooth muscle development IEA
Inferred from Electronic Annotation
more info
 
involved_in megakaryocyte development IEA
Inferred from Electronic Annotation
more info
 
involved_in mesoderm formation IEA
Inferred from Electronic Annotation
more info
 
involved_in morphogenesis of an epithelial sheet IEA
Inferred from Electronic Annotation
more info
 
involved_in muscle cell cellular homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of amyloid-beta clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of miRNA transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron development TAS
Traceable Author Statement
more info
PubMed 
involved_in neuron migration IEA
Inferred from Electronic Annotation
more info
 
involved_in platelet activation IEA
Inferred from Electronic Annotation
more info
 
involved_in platelet formation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of axon extension IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of filopodium assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of miRNA transcription IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of miRNA transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of smooth muscle contraction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription by glucose IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription initiation by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive thymic T cell selection IEA
Inferred from Electronic Annotation
more info
 
involved_in primitive streak formation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of smooth muscle cell differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of water loss via skin IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cytokine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to cytokine NAS
Non-traceable Author Statement
more info
PubMed 
involved_in response to hormone IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to toxic substance TAS
Traceable Author Statement
more info
PubMed 
involved_in sarcomere organization IEA
Inferred from Electronic Annotation
more info
 
involved_in skin morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in stress fiber assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in tangential migration from the subventricular zone to the olfactory bulb IEA
Inferred from Electronic Annotation
more info
 
involved_in thymus development IEA
Inferred from Electronic Annotation
more info
 
involved_in thyroid gland development IEA
Inferred from Electronic Annotation
more info
 
involved_in trachea cartilage development IEA
Inferred from Electronic Annotation
more info
 
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within trophectodermal cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serum response factor
Names
c-fos serum response element-binding transcription factor
minichromosome maintenance 1 homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001292001.2NP_001278930.1  serum response factor isoform 2

    See identical proteins and their annotated locations for NP_001278930.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK300467, BC052572
    UniProtKB/Swiss-Prot
    P11831
    UniProtKB/TrEMBL
    B4DU24
  2. NM_003131.4NP_003122.1  serum response factor isoform 1

    See identical proteins and their annotated locations for NP_003122.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL355385, BC052572
    Consensus CDS
    CCDS4889.1
    UniProtKB/Swiss-Prot
    P11831, Q5T648
    UniProtKB/TrEMBL
    A0A024RD16
    Related
    ENSP00000265354.4, ENST00000265354.6
    Conserved Domains (1) summary
    cd00266
    Location:142223
    MADS_SRF_like; SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    43171269..43181506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419268.1XP_047275224.1  serum response factor isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    43000031..43010279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)