U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Eif2s2 eukaryotic translation initiation factor 2 subunit 2 beta [ Mus musculus (house mouse) ]

Gene ID: 67204, updated on 8-Feb-2024

Summary

Official Symbol
Eif2s2provided by MGI
Official Full Name
eukaryotic translation initiation factor 2 subunit 2 betaprovided by MGI
Primary source
MGI:MGI:1914454
See related
Ensembl:ENSMUSG00000074656 AllianceGenome:MGI:1914454
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EIF2; 38kDa; EIF2B; D2Ertd303e; 2810026E11Rik
Summary
Predicted to enable mRNA binding activity; translation initiation factor activity; and translation initiation factor binding activity. Acts upstream of or within in utero embryonic development; male germ cell proliferation; and male gonad development. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 2 complex. Is expressed in several structures, including blastocyst; colon; early embryo; gonad; and liver. Orthologous to human EIF2S2 (eukaryotic translation initiation factor 2 subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 37.7), placenta adult (RPKM 37.6) and 22 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Eif2s2 in Genome Data Viewer
Location:
2 H1; 2 76.89 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (154713330..154734826, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (154871410..154892906, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 38598 Neighboring gene STARR-positive B cell enhancer ABC_E1013 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene hnRNP-associated with lethal yellow Neighboring gene STARR-positive B cell enhancer ABC_E7874 Neighboring gene STARR-seq mESC enhancer starr_06136 Neighboring gene STARR-seq mESC enhancer starr_06137 Neighboring gene nonagouti Neighboring gene STARR-positive B cell enhancer ABC_E9207 Neighboring gene STARR-positive B cell enhancer mm9_chr2:154876406-154876706 Neighboring gene predicted gene, 39965 Neighboring gene STARR-positive B cell enhancer ABC_E2054 Neighboring gene predicted gene, 39966 Neighboring gene S-adenosylhomocysteine hydrolase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC130606

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
 
enables translation initiation factor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in cytoplasmic translational initiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoplasmic translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in formation of translation preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within male germ cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
 
involved_in translational initiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of eukaryotic translation initiation factor 2 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of eukaryotic translation initiation factor 2 complex ISO
Inferred from Sequence Orthology
more info
 
part_of eukaryotic translation initiation factor 2 complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
eukaryotic translation initiation factor 2 subunit 2
Names
eIF-2-beta
eIF2-beta
eukaryotic translation initiation factor 2 subunit beta
eukaryotic translation initiation factor 2, subunit 2 (beta, 38kDa)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026030.2NP_080306.1  eukaryotic translation initiation factor 2 subunit 2

    See identical proteins and their annotated locations for NP_080306.1

    Status: VALIDATED

    Source sequence(s)
    AK166862, AL929024, CJ084276
    Consensus CDS
    CCDS38292.1
    UniProtKB/Swiss-Prot
    Q99L45, Q9CSH6, Q9CT12
    UniProtKB/TrEMBL
    Q3ULL5
    Related
    ENSMUSP00000096777.5, ENSMUST00000099173.11
    Conserved Domains (1) summary
    smart00653
    Location:197306
    eIF2B_5; domain present in translation initiation factor eIF2B and eIF5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    154713330..154734826 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)