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Mtdh metadherin [ Mus musculus (house mouse) ]

Gene ID: 67154, updated on 12-Oct-2019

Summary

Official Symbol
Mtdhprovided by MGI
Official Full Name
metadherinprovided by MGI
Primary source
MGI:MGI:1914404
See related
Ensembl:ENSMUSG00000022255
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3D3; AEG-1; Lyric; AV353288; 3D3/Lyric; D8Bwg1112e; 2610103J23Rik
Expression
Ubiquitous expression in CNS E11.5 (RPKM 15.3), bladder adult (RPKM 13.4) and 28 other tissues See more
Orthologs

Genomic context

See Mtdh in Genome Data Viewer
Location:
15 B3.1; 15 13.98 cM
Exon count:
14
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (34082442..34143537)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (34012474..34072140)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene predicted gene 9643 Neighboring gene predicted gene, 41290 Neighboring gene predicted gene, 41291 Neighboring gene predicted gene, 38594 Neighboring gene lysosomal-associated protein transmembrane 4B Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NF-kappaB binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
fibrillar center ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intercellular canaliculus ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear body ISO
Inferred from Sequence Orthology
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein LYRIC
Names
lysine-rich CEACAM1 co-isolated protein
metastasis adhesion protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357925.1NP_001344854.1  protein LYRIC isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks exons in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC149588
    Conserved Domains (1) summary
    pfam15686
    Location:6386
    LYRIC; Lysine-rich CEACAM1 co-isolated protein family
  2. NM_001357926.1NP_001344855.1  protein LYRIC isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC149588
    Conserved Domains (1) summary
    pfam15686
    Location:6449
    LYRIC; Lysine-rich CEACAM1 co-isolated protein family
  3. NM_026002.5NP_080278.3  protein LYRIC isoform 3

    See identical proteins and their annotated locations for NP_080278.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AC149588
    Consensus CDS
    CCDS27415.1
    UniProtKB/Swiss-Prot
    Q80WJ7
    Related
    ENSMUSP00000022865.9, ENSMUST00000022865.16
    Conserved Domains (1) summary
    pfam15686
    Location:6419
    LYRIC; Lysine-rich CEACAM1 co-isolated protein family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000081.6 Reference GRCm38.p6 C57BL/6J

    Range
    34082442..34143537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520151.2XP_006520214.1  protein LYRIC isoform X2

    Conserved Domains (1) summary
    pfam15686
    Location:6449
    LYRIC; Lysine-rich CEACAM1 co-isolated protein family
  2. XM_017316729.2XP_017172218.1  protein LYRIC isoform X4

  3. XM_006520152.2XP_006520215.1  protein LYRIC isoform X7

    Related
    ENSMUSP00000130190.2, ENSMUST00000163333.8
    Conserved Domains (1) summary
    pfam15686
    Location:6386
    LYRIC; Lysine-rich CEACAM1 co-isolated protein family
  4. XM_006520149.2XP_006520212.1  protein LYRIC isoform X1

    Conserved Domains (1) summary
    pfam15686
    Location:6390
    LYRIC; Lysine-rich CEACAM1 co-isolated protein family
  5. XM_017316731.2XP_017172220.1  protein LYRIC isoform X6

  6. XM_017316728.2XP_017172217.1  protein LYRIC isoform X3

  7. XM_017316730.2XP_017172219.1  protein LYRIC isoform X5

  8. XM_030248710.1XP_030104570.1  protein LYRIC isoform X8

    Related
    ENSMUSP00000131814.1, ENSMUST00000169905.1
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