Ramac RNA guanine-7 methyltransferase activating subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ramacprovided by MGI
Official Full Name: RNA guanine-7 methyltransferase activating subunitprovided by MGI
Primary source: MGI:MGI:1914398
See related: Ensembl:ENSMUSG00000038646 AllianceGenome:MGI:1914398
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RAM; Rammet; Fam103a1; 2410047I02Rik; 2610204K14Rik
Summary: Predicted to enable RNA binding activity and enzyme activator activity. Predicted to be involved in methylation and recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex. Predicted to act upstream of or within mRNA processing. Predicted to be located in nucleoplasm. Predicted to be part of mRNA cap binding activity complex and mRNA cap methyltransferase complex. Is expressed in embryo. Orthologous to human RAMAC (RNA guanine-7 methyltransferase activating subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 29.5), CNS E18 (RPKM 25.4) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7; 7 D3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (81412701..81419238)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (81762953..81769490)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126546 (e-PCR)
- UniSTS:209677

RH140483 (e-PCR)
- UniSTS:222555

Homology

Homologs of the Ramac gene: The Ramac gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, and chicken.
Orthologs from Annotation Pipeline: 338 organisms have orthologs with human gene Ramac
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables enzyme activator activity	ISO Inferred from Sequence Orthology more info
enables molecular function activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within 7-methylguanosine mRNA capping	IEA Inferred from Electronic Annotation more info
involved_in RNA 5'-cap (guanine-N7)-methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in methylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
part_of mRNA cap binding complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of mRNA cap binding complex	ISO Inferred from Sequence Orthology more info
part_of mRNA cap methyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of mRNA cap methyltransferase complex	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RNA guanine-N7 methyltransferase activating subunit

Names: RNMT actvating mRNA cap methylating subunit; RNMT-activating mRNA cap methylating subunit; RNMT-activating mRNA cap methyltransferase subunit; RNMT-activating mini protein; family with sequence similarity 103, member A1; protein FAM103A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.