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Herc6 hect domain and RLD 6 [ Mus musculus (house mouse) ]

Gene ID: 67138, updated on 12-May-2024

Summary

Official Symbol
Herc6provided by MGI
Official Full Name
hect domain and RLD 6provided by MGI
Primary source
MGI:MGI:1914388
See related
Ensembl:ENSMUSG00000029798 AllianceGenome:MGI:1914388
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CEB1; Herc5; 1700121D12Rik; 2510038N07Rik; 4930427L17Rik
Summary
Predicted to enable cyclin binding activity and ubiquitin protein ligase activity. Acts upstream of or within hematopoietic progenitor cell differentiation and response to bacterium. Predicted to be located in cytosol and nucleoplasm. Is expressed in liver. Orthologous to human HERC6 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E18 (RPKM 2.1), cortex adult (RPKM 1.7) and 28 other tissues See more
Orthologs
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Genomic context

See Herc6 in Genome Data Viewer
Location:
6 B3; 6 27.82 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (57557977..57642121)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (57580992..57665136)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930533I22 gene Neighboring gene predicted gene, 50628 Neighboring gene protein phosphatase 1K (PP2C domain containing) Neighboring gene STARR-positive B cell enhancer ABC_E342 Neighboring gene STARR-seq mESC enhancer starr_16003 Neighboring gene STARR-positive B cell enhancer ABC_E9666 Neighboring gene ribosomal protein S27 pseudogene Neighboring gene STARR-seq mESC enhancer starr_16006 Neighboring gene Pigy upstream reading frame Neighboring gene LanC (bacterial lantibiotic synthetase component C)-like 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

General gene information

Markers

Clone Names

  • KIAA0032

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ISG15--protein ligase Herc6
Names
hect domain and RLD 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025992.2NP_080268.1  E3 ISG15--protein ligase Herc6

    See identical proteins and their annotated locations for NP_080268.1

    Status: VALIDATED

    Source sequence(s)
    AC127307, AC142212
    Consensus CDS
    CCDS51796.1
    UniProtKB/Swiss-Prot
    F2Z461, Q3UEA7, Q9CU70
    Related
    ENSMUSP00000031817.9, ENSMUST00000031817.10
    Conserved Domains (5) summary
    smart00119
    Location:682999
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:658999
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:145195
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:237266
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat
    cl02777
    Location:570652
    chaperonin_like; chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    57557977..57642121
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_028861.1: Suppressed sequence

    Description
    NM_028861.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.