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Ndufa6 NADH:ubiquinone oxidoreductase subunit A6 [ Mus musculus (house mouse) ]

Gene ID: 67130, updated on 6-Oct-2024

Summary

Official Symbol
Ndufa6provided by MGI
Official Full Name
NADH:ubiquinone oxidoreductase subunit A6provided by MGI
Primary source
MGI:MGI:1914380
See related
Ensembl:ENSMUSG00000022450 AllianceGenome:MGI:1914380
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
14kDa; 2700038D15Rik; B230217P19Rik
Summary
Predicted to be involved in mitochondrial respiratory chain complex I assembly and response to oxidative stress. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 33. Orthologous to human NDUFA6 (NADH:ubiquinone oxidoreductase subunit A6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E18 (RPKM 198.9), kidney adult (RPKM 184.9) and 28 other tissues See more
Orthologs
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Genomic context

See Ndufa6 in Genome Data Viewer
Location:
15 E1; 15 38.56 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (82234342..82238438, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (82350139..82354291, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene PH domain containing endocytic trafficking adaptor 2 Neighboring gene STARR-seq mESC enhancer starr_39293 Neighboring gene nuclear encoded rRNA 5S 41 Neighboring gene single-pass membrane protein with aspartate rich tail 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:82192158-82192359 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 22 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 11 Neighboring gene microRNA 7684

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in aerobic respiration NAS
Non-traceable Author Statement
more info
PubMed 
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial respiratory chain complex I assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in proton motive force-driven mitochondrial ATP synthesis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
 
part_of respiratory chain complex I ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
Names
CI-B14
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6 (B14)
NADH-ubiquinone oxidoreductase B14 subunit
complex I-B14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025987.4NP_080263.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

    See identical proteins and their annotated locations for NP_080263.1

    Status: VALIDATED

    Source sequence(s)
    AC104325
    Consensus CDS
    CCDS27689.1
    UniProtKB/Swiss-Prot
    Q9CQZ5
    Related
    ENSMUSP00000023085.6, ENSMUST00000023085.7
    Conserved Domains (1) summary
    cd20266
    Location:28102
    Complex1_LYR_NDUFA6_LYRM6; LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (NDUFA6) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    82234342..82238438 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)