U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ttc14 tetratricopeptide repeat domain 14 [ Mus musculus (house mouse) ]

Gene ID: 67120, updated on 6-Jun-2024

Summary

Official Symbol
Ttc14provided by MGI
Official Full Name
tetratricopeptide repeat domain 14provided by MGI
Primary source
MGI:MGI:1914370
See related
Ensembl:ENSMUSG00000027677 AllianceGenome:MGI:1914370
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
cI-44; mKIAA1980; 2700016E08Rik; 4930434D01Rik; 4931403I22Rik; 4933402I15Rik
Summary
Predicted to enable nucleic acid binding activity. Orthologous to human TTC14 (tetratricopeptide repeat domain 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 13.0), cortex adult (RPKM 11.9) and 26 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Ttc14 in Genome Data Viewer
Location:
3 A3; 3 16.32 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (33853923..33869009)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (33799798..33814860)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42203 Neighboring gene heat shock protein 1 (chaperonin) pseudogene Neighboring gene coiled-coil domain containing 39 Neighboring gene STARR-seq mESC enhancer starr_07362 Neighboring gene predicted gene, 42204 Neighboring gene STARR-positive B cell enhancer ABC_E11180 Neighboring gene predicted gene, 23175

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA1980

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
tetratricopeptide repeat protein 14
Names
TPR repeat protein 14

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290500.2NP_001277429.1  tetratricopeptide repeat protein 14 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC154395
    Consensus CDS
    CCDS71232.1
    UniProtKB/Swiss-Prot
    G3X9T5, Q69Z51, Q8BRX6, Q8CD24, Q8CDF8, Q8R3Q9, Q9CSP9
    UniProtKB/TrEMBL
    E9PXW3
    Related
    ENSMUSP00000112450.4, ENSMUST00000117915.8
    Conserved Domains (4) summary
    smart00316
    Location:123206
    S1; Ribosomal protein S1-like RNA-binding domain
    sd00006
    Location:254282
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:288321
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:254319
    TPR_11; TPR repeat
  2. NM_001290502.2NP_001277431.1  tetratricopeptide repeat protein 14 isoform d

    See identical proteins and their annotated locations for NP_001277431.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in both UTRs, uses an alternate splice site in the 5' coding region and an alternate 3' terminal exon. These difference cause translation initiation at an alternate start codon compared to variant 1. The encoded isoform (d) is shorter and has novel N- and C-termini compared to isoform a.
    Source sequence(s)
    AC154395
    Consensus CDS
    CCDS79895.1
    UniProtKB/TrEMBL
    A0A0G2JGX7
    Related
    ENSMUSP00000143738.2, ENSMUST00000200271.5
    Conserved Domains (4) summary
    smart00316
    Location:120203
    S1; Ribosomal protein S1-like RNA-binding domain
    sd00006
    Location:303331
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:337370
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:303368
    TPR_11; TPR repeat
  3. NM_001404037.1NP_001390966.1  tetratricopeptide repeat protein 14 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC154395
    UniProtKB/TrEMBL
    A0A0G2JEQ6
  4. NM_001404038.1NP_001390967.1  tetratricopeptide repeat protein 14 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC154395
    UniProtKB/TrEMBL
    A0A0G2JEQ6
  5. NM_001404039.1NP_001390968.1  tetratricopeptide repeat protein 14 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC154395
    UniProtKB/TrEMBL
    A0A0G2JEQ6
    Related
    ENSMUSP00000142863.2, ENSMUST00000196369.2
  6. NM_001404040.1NP_001390969.1  tetratricopeptide repeat protein 14 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC154395
    UniProtKB/TrEMBL
    A0A0G2JEQ6
  7. NM_001404041.1NP_001390970.1  tetratricopeptide repeat protein 14 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC154395
    UniProtKB/TrEMBL
    A0A0G2JEQ6
  8. NM_001404042.1NP_001390971.1  tetratricopeptide repeat protein 14 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC154395
    UniProtKB/Swiss-Prot
    G3X9T5, Q69Z51, Q8BRX6, Q8CD24, Q8CDF8, Q8R3Q9, Q9CSP9
  9. NM_025978.5NP_080254.2  tetratricopeptide repeat protein 14 isoform b

    See identical proteins and their annotated locations for NP_080254.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate structure in the 3' UTR and 3' coding region compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC154395
    Consensus CDS
    CCDS17303.1
    UniProtKB/TrEMBL
    A0A0G2JE97, A6H6N9
    Related
    ENSMUSP00000096757.4, ENSMUST00000099153.10
    Conserved Domains (4) summary
    smart00316
    Location:123206
    S1; Ribosomal protein S1-like RNA-binding domain
    sd00006
    Location:306334
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:340373
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:306371
    TPR_11; TPR repeat
  10. NM_027619.5NP_081895.2  tetratricopeptide repeat protein 14 isoform a

    See identical proteins and their annotated locations for NP_081895.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform (a).
    Source sequence(s)
    AC154395
    Consensus CDS
    CCDS38410.1
    UniProtKB/Swiss-Prot
    G3X9T5, Q69Z51, Q8BRX6, Q8CD24, Q8CDF8, Q8R3Q9, Q9CSP9
    UniProtKB/TrEMBL
    A0A8V5I5B0
    Related
    ENSMUSP00000103845.5, ENSMUST00000108210.9
    Conserved Domains (4) summary
    smart00316
    Location:123206
    S1; Ribosomal protein S1-like RNA-binding domain
    sd00006
    Location:306334
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:340373
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:306371
    TPR_11; TPR repeat

RNA

  1. NR_175794.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154395
  2. NR_175795.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154395
  3. NR_175796.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154395
  4. NR_175797.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154395
  5. NR_175798.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154395

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    33853923..33869009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163240.1XP_036019133.1  tetratricopeptide repeat protein 14 isoform X7

    UniProtKB/TrEMBL
    A0A0G2JEX0, A0A0G2JF90
    Related
    ENSMUSP00000142935.2, ENSMUST00000199222.5
    Conserved Domains (3) summary
    smart00316
    Location:123206
    S1; Ribosomal protein S1-like RNA-binding domain
    COG0457
    Location:289430
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:306334
    TPR; TPR repeat [structural motif]
  2. XM_006535522.4XP_006535585.1  tetratricopeptide repeat protein 14 isoform X1

    UniProtKB/Swiss-Prot
    G3X9T5, Q69Z51, Q8BRX6, Q8CD24, Q8CDF8, Q8R3Q9, Q9CSP9
    Conserved Domains (3) summary
    smart00316
    Location:154237
    S1; Ribosomal protein S1-like RNA-binding domain
    COG0457
    Location:256415
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:285313
    TPR; TPR repeat [structural motif]
  3. XM_011249707.4XP_011248009.1  tetratricopeptide repeat protein 14 isoform X6

    UniProtKB/TrEMBL
    A0A0G2JF90
    Conserved Domains (3) summary
    smart00316
    Location:154237
    S1; Ribosomal protein S1-like RNA-binding domain
    COG0457
    Location:320461
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:337365
    TPR; TPR repeat [structural motif]
  4. XM_011249706.4XP_011248008.1  tetratricopeptide repeat protein 14 isoform X5

    UniProtKB/TrEMBL
    A0A0G2JF90
    Conserved Domains (3) summary
    smart00316
    Location:154237
    S1; Ribosomal protein S1-like RNA-binding domain
    COG0457
    Location:320473
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:337365
    TPR; TPR repeat [structural motif]
  5. XM_036163238.1XP_036019131.1  tetratricopeptide repeat protein 14 isoform X3

    Conserved Domains (3) summary
    COG0457
    Location:75222
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:92120
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:102140
    TPR_11; TPR repeat
  6. XM_030252768.2XP_030108628.1  tetratricopeptide repeat protein 14 isoform X4

    Conserved Domains (3) summary
    COG0457
    Location:11170
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:4068
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:5088
    TPR_11; TPR repeat

RNA

  1. XR_880651.4 RNA Sequence