U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cuedc2 CUE domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 67116, updated on 9-May-2024

Summary

Official Symbol
Cuedc2provided by MGI
Official Full Name
CUE domain containing 2provided by MGI
Primary source
MGI:MGI:1914366
See related
Ensembl:ENSMUSG00000036748 AllianceGenome:MGI:1914366
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3010002G01Rik
Summary
Predicted to enable ubiquitin binding activity. Acts upstream of or within negative regulation of cytokine production involved in inflammatory response and negative regulation of macrophage cytokine production. Predicted to be located in cytosol; nuclear membrane; and nucleoplasm. Is expressed in cerebral cortex subventricular zone; cerebral cortex ventricular layer; and cortical plate. Orthologous to human CUEDC2 (CUE domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 37.4), CNS E14 (RPKM 32.7) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Cuedc2 in Genome Data Viewer
Location:
19 C3; 19 38.81 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (46318251..46327144, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (46329812..46338672, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 Neighboring gene RIKEN cDNA 4833438C02 gene Neighboring gene STARR-positive B cell enhancer ABC_E9457 Neighboring gene pleckstrin and Sec7 domain containing Neighboring gene F-box and leucine-rich repeat protein 15 Neighboring gene STARR-positive B cell enhancer ABC_E973 Neighboring gene predicted gene, 36493 Neighboring gene microRNA 146b Neighboring gene RIKEN cDNA 2310034G01 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

General protein information

Preferred Names
CUE domain-containing protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164290.1NP_001157762.1  CUE domain-containing protein 2 isoform a

    See identical proteins and their annotated locations for NP_001157762.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, 3 and 4 encode the same isoform (a).
    Source sequence(s)
    AC114539, AK008842, AK013884, BY279028, CX207621, CX218143, CX223880
    Consensus CDS
    CCDS29876.1
    UniProtKB/Swiss-Prot
    Q99LC1, Q9CXX9
    UniProtKB/TrEMBL
    Q9CVB0
    Related
    ENSMUSP00000129589.2, ENSMUST00000167861.8
    Conserved Domains (1) summary
    cd14367
    Location:144183
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
  2. NM_001164291.1NP_001157763.1  CUE domain-containing protein 2 isoform a

    See identical proteins and their annotated locations for NP_001157763.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (a).
    Source sequence(s)
    AC114539, AK008842, AK013884, BY279028, CX207621
    Consensus CDS
    CCDS29876.1
    UniProtKB/Swiss-Prot
    Q99LC1, Q9CXX9
    UniProtKB/TrEMBL
    Q9CVB0
    Related
    ENSMUSP00000053469.9, ENSMUST00000051234.9
    Conserved Domains (1) summary
    cd14367
    Location:144183
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
  3. NM_001164292.1NP_001157764.1  CUE domain-containing protein 2 isoform a

    See identical proteins and their annotated locations for NP_001157764.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (a).
    Source sequence(s)
    AC114539, AK008842, AK013884, BY279028
    Consensus CDS
    CCDS29876.1
    UniProtKB/Swiss-Prot
    Q99LC1, Q9CXX9
    UniProtKB/TrEMBL
    Q9CVB0
    Related
    ENSMUSP00000158425.2, ENSMUST00000235485.2
    Conserved Domains (1) summary
    cd14367
    Location:144183
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
  4. NM_001164293.1NP_001157765.1  CUE domain-containing protein 2 isoform b

    See identical proteins and their annotated locations for NP_001157765.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform b) is shorter than isoform a.
    Source sequence(s)
    AC114539, AK008842, AK013884, BY279028, BY312150
    Consensus CDS
    CCDS89410.1
    UniProtKB/TrEMBL
    A0A494BAT2, Q9CVB0
    Related
    ENSMUSP00000158178.2, ENSMUST00000235977.2
    Conserved Domains (1) summary
    cd14367
    Location:133172
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
  5. NM_001164294.1NP_001157766.1  CUE domain-containing protein 2 isoform c

    See identical proteins and their annotated locations for NP_001157766.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform c) is shorter than isoform a. Variants 6 and 7 encode the same isoform (c).
    Source sequence(s)
    AC114539, AK008842, AK013884, BY279028, CK625575
    Consensus CDS
    CCDS89409.1
    UniProtKB/TrEMBL
    A0A494BB93, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:126165
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
  6. NM_001164295.1NP_001157767.1  CUE domain-containing protein 2 isoform c

    See identical proteins and their annotated locations for NP_001157767.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform c) is shorter than isoform a. Variants 6 and 7 encode the same isoform (c).
    Source sequence(s)
    AC114539, AK008842, AK013884, BY279028
    Consensus CDS
    CCDS89409.1
    UniProtKB/TrEMBL
    A0A494BB93, Q9CVB0
    Related
    ENSMUSP00000158362.2, ENSMUST00000236980.2
    Conserved Domains (1) summary
    cd14367
    Location:126165
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
  7. NM_024192.2NP_077154.2  CUE domain-containing protein 2 isoform a

    See identical proteins and their annotated locations for NP_077154.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (a).
    Source sequence(s)
    AC114539, AK008842, AK013884, BY279028, CX207621, CX223880
    Consensus CDS
    CCDS29876.1
    UniProtKB/Swiss-Prot
    Q99LC1, Q9CXX9
    UniProtKB/TrEMBL
    Q9CVB0
    Related
    ENSMUSP00000157840.2, ENSMUST00000236061.2
    Conserved Domains (1) summary
    cd14367
    Location:144183
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    46318251..46327144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251035.2XP_030106895.1  CUE domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A494BAT2, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:133172
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
  2. XM_006527276.4XP_006527339.1  CUE domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006527339.1

    UniProtKB/Swiss-Prot
    Q99LC1, Q9CXX9
    UniProtKB/TrEMBL
    Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:144183
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
  3. XM_030251041.2XP_030106901.1  CUE domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A494BB93, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:126165
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
  4. XM_030251036.2XP_030106896.1  CUE domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A494BAT2, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:133172
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
  5. XM_011247321.3XP_011245623.1  CUE domain-containing protein 2 isoform X3

    See identical proteins and their annotated locations for XP_011245623.1

    UniProtKB/TrEMBL
    A0A494BB93, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:126165
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
  6. XM_011247320.3XP_011245622.1  CUE domain-containing protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011245622.1

    UniProtKB/TrEMBL
    A0A494BAT2, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:133172
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
  7. XM_030251043.2XP_030106903.1  CUE domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A494BB93, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:126165
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
  8. XM_036161662.1XP_036017555.1  CUE domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A494BAT2, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:133172
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
  9. XM_030251033.2XP_030106893.1  CUE domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q99LC1, Q9CXX9
    UniProtKB/TrEMBL
    Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:144183
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
  10. XM_030251040.2XP_030106900.1  CUE domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A494BB93, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:126165
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
  11. XM_006527280.3XP_006527343.1  CUE domain-containing protein 2 isoform X3

    See identical proteins and their annotated locations for XP_006527343.1

    UniProtKB/TrEMBL
    A0A494BB93, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:126165
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
  12. XM_006527278.4XP_006527341.1  CUE domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006527341.1

    UniProtKB/Swiss-Prot
    Q99LC1, Q9CXX9
    UniProtKB/TrEMBL
    Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:144183
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
  13. XM_030251039.2XP_030106899.1  CUE domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A494BB93, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:126165
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
  14. XM_011247318.3XP_011245620.1  CUE domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011245620.1

    UniProtKB/Swiss-Prot
    Q99LC1, Q9CXX9
    UniProtKB/TrEMBL
    Q9CVB0
    Related
    ENSMUSP00000157580.2, ENSMUST00000236046.2
    Conserved Domains (1) summary
    cd14367
    Location:144183
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
  15. XM_030251037.2XP_030106897.1  CUE domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A494BAT2, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:133172
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
  16. XM_006527277.5XP_006527340.1  CUE domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006527340.1

    UniProtKB/Swiss-Prot
    Q99LC1, Q9CXX9
    UniProtKB/TrEMBL
    Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:144183
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
  17. XM_006527279.5XP_006527342.1  CUE domain-containing protein 2 isoform X3

    See identical proteins and their annotated locations for XP_006527342.1

    UniProtKB/TrEMBL
    A0A494BB93, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:126165
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
  18. XM_030251034.2XP_030106894.1  CUE domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A494BAT2, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:133172
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
  19. XM_006527275.5XP_006527338.1  CUE domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006527338.1

    UniProtKB/Swiss-Prot
    Q99LC1, Q9CXX9
    UniProtKB/TrEMBL
    Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:144183
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
  20. XM_030251042.2XP_030106902.1  CUE domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A494BB93, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:126165
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
  21. XM_011247319.3XP_011245621.1  CUE domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011245621.1

    UniProtKB/Swiss-Prot
    Q99LC1, Q9CXX9
    UniProtKB/TrEMBL
    Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:144183
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
  22. XM_030251038.2XP_030106898.1  CUE domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A494BB93, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:126165
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
  23. XM_036161660.1XP_036017553.1  CUE domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A494BAT2, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:133172
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
  24. XM_030251044.1XP_030106904.1  CUE domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A494BB93, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:126165
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
  25. XM_011247317.3XP_011245619.1  CUE domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011245619.1

    UniProtKB/Swiss-Prot
    Q99LC1, Q9CXX9
    UniProtKB/TrEMBL
    Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:144183
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins