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Ptgr1 prostaglandin reductase 1 [ Mus musculus (house mouse) ]

Gene ID: 67103, updated on 30-Apr-2024

Summary

Official Symbol
Ptgr1provided by MGI
Official Full Name
prostaglandin reductase 1provided by MGI
Primary source
MGI:MGI:1914353
See related
Ensembl:ENSMUSG00000028378 AllianceGenome:MGI:1914353
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DIG-1; Zadh3; Ltb4dh; 2510002C21Rik
Summary
Predicted to enable 13-prostaglandin reductase activity; 15-oxoprostaglandin 13-oxidase activity; and 2-alkenal reductase (NADP+) activity. Predicted to be involved in prostaglandin metabolic process. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in cytoplasm. Is expressed in genitourinary system. Orthologous to human PTGR1 (prostaglandin reductase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 46.6), stomach adult (RPKM 29.1) and 12 other tissues See more
Orthologs
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Genomic context

See Ptgr1 in Genome Data Viewer
Location:
4 B3; 4 32.36 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (58965590..58987131, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (58965590..58987131, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Ecm29 proteasome adaptor and scaffold Neighboring gene STARR-positive B cell enhancer ABC_E6181 Neighboring gene zinc finger with KRAB and SCAN domains 16 Neighboring gene STARR-positive B cell enhancer ABC_E9587 Neighboring gene DnaJ heat shock protein family (Hsp40) member C25 Neighboring gene guanine nucleotide binding protein (G protein), gamma 10

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 13-prostaglandin reductase activity ISO
Inferred from Sequence Orthology
more info
 
enables 15-oxoprostaglandin 13-oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 2-alkenal reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
 
enables 2-alkenal reductase [NAD(P)+] activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in prostaglandin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in prostaglandin metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
prostaglandin reductase 1
Names
15-oxoprostaglandin 13-reductase
D3T-inducible gene 1 protein
NAD(P)H-dependent alkenal/one oxidoreductase
NADP-dependent leukotriene B4 12-hydroxydehydrogenase
PRG-1
dithiolethione-inducible gene 1 protein
leukotriene B4 12-hydroxydehydrogenase
NP_080244.1
XP_011248390.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025968.3NP_080244.1  prostaglandin reductase 1

    See identical proteins and their annotated locations for NP_080244.1

    Status: PROVISIONAL

    Source sequence(s)
    AK035425
    Consensus CDS
    CCDS18215.1
    UniProtKB/Swiss-Prot
    Q3TKT6, Q91YR9, Q9CPS1
    UniProtKB/TrEMBL
    Q4FJY5
    Related
    ENSMUSP00000030069.7, ENSMUST00000030069.7
    Conserved Domains (2) summary
    TIGR02825
    Location:4328
    B4_12hDH; leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase
    cd08294
    Location:2329
    leukotriene_B4_DH_like; 13-PGR is a bifunctional enzyme with delta-13 15-prostaglandin reductase and leukotriene B4 12 hydroxydehydrogenase activity

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    58965590..58987131 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250088.1XP_011248390.1  prostaglandin reductase 1 isoform X1

    Conserved Domains (1) summary
    TIGR02825
    Location:4263
    B4_12hDH; leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase