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Trak1 trafficking protein, kinesin binding 1 [ Mus musculus (house mouse) ]

Gene ID: 67095, updated on 8-Dec-2022

Summary

Official Symbol
Trak1provided by MGI
Official Full Name
trafficking protein, kinesin binding 1provided by MGI
Primary source
MGI:MGI:1914345
See related
Ensembl:ENSMUSG00000032536 AllianceGenome:MGI:1914345
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
hyrt; mKIAA1042; 2310001H13Rik
Summary
Enables GABA receptor binding activity. Involved in anterograde axonal transport of mitochondrion. Predicted to be located in axonal growth cone; early endosome; and perinuclear region of cytoplasm. Predicted to be active in cytoplasmic vesicle; dendrite; and mitochondrion. Is expressed in several structures, including central nervous system; dorsal root ganglion; liver; spleen; and submandibular gland primordium. Used to study Stiff-Person syndrome. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 68. Orthologous to human TRAK1 (trafficking kinesin protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 26.4), heart adult (RPKM 14.9) and 26 other tissues See more
Orthologs
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Genomic context

See Trak1 in Genome Data Viewer
Location:
9 F4; 9 72.41 cM
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (121126568..121303985)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (121297502..121474919)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene unc-51-like kinase 4 Neighboring gene predicted gene, 34735 Neighboring gene VISTA enhancer mm1661 Neighboring gene predicted gene, 34655 Neighboring gene predicted gene, 51661 Neighboring gene predicted gene, 38661 Neighboring gene predicted gene, 47095 Neighboring gene cholecystokinin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Endonuclease-mediated (2) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GABA receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GABA receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables TPR domain binding ISO
Inferred from Sequence Orthology
more info
 
enables myosin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in anterograde axonal transport of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in anterograde axonal transport of mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axonal transport of mitochondrion ISO
Inferred from Sequence Orthology
more info
 
involved_in dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in endosome to lysosome transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrion distribution IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of axonogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein targeting IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in axonal growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
trafficking kinesin-binding protein 1
Names
protein Milton

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357968.1NP_001344897.1  trafficking kinesin-binding protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC115863, AC131660
    Conserved Domains (2) summary
    pfam04849
    Location:45302
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:363530
    Milton; Kinesin associated protein
  2. NM_001357969.1NP_001344898.1  trafficking kinesin-binding protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC115863, AC131660
    Conserved Domains (2) summary
    pfam04849
    Location:1249
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:310477
    Milton; Kinesin associated protein
  3. NM_001357970.1NP_001344899.1  trafficking kinesin-binding protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC115863, AC131660
    Conserved Domains (2) summary
    pfam04849
    Location:1249
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:310477
    Milton; Kinesin associated protein
  4. NM_001357972.1NP_001344901.1  trafficking kinesin-binding protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC115863, AK029123, AK041436, BE957084
    Consensus CDS
    CCDS90685.1
    UniProtKB/TrEMBL
    A0A1B0GSQ2
    Related
    ENSMUSP00000148026.2, ENSMUST00000211439.2
    Conserved Domains (2) summary
    pfam04849
    Location:1249
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:310476
    Milton; Kinesin associated protein
  5. NM_001357973.1NP_001344902.1  trafficking kinesin-binding protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC115863
    Consensus CDS
    CCDS90684.1
    UniProtKB/TrEMBL
    Q80VE1
    Related
    ENSMUSP00000148092.2, ENSMUST00000210636.2
    Conserved Domains (1) summary
    pfam04849
    Location:49231
    HAP1_N; HAP1 N-terminal conserved region
  6. NM_175114.4NP_780323.2  trafficking kinesin-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_780323.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC115863, AC131660
    Consensus CDS
    CCDS40810.1
    UniProtKB/Swiss-Prot
    Q6PD31, Q8BYA3
    Related
    ENSMUSP00000044482.7, ENSMUST00000045903.8
    Conserved Domains (4) summary
    pfam04849
    Location:49352
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:421580
    Milton; Kinesin associated protein
    cl12013
    Location:132345
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl21478
    Location:263355
    ATP-synt_B; ATP synthase B/B' CF(0)

RNA

  1. NR_152160.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC115863, AC131660, AK029123, AK041436
    Related
    ENSMUST00000210798.3

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    121126568..121303985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)