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SPRR3 small proline rich protein 3 [ Homo sapiens (human) ]

Gene ID: 6707, updated on 5-Aug-2022

Summary

Official Symbol
SPRR3provided by HGNC
Official Full Name
small proline rich protein 3provided by HGNC
Primary source
HGNC:HGNC:11268
See related
Ensembl:ENSG00000163209 MIM:182271; AllianceGenome:HGNC:11268
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable structural molecule activity. Predicted to be involved in wound healing. Located in Golgi apparatus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward esophagus (RPKM 6973.3) See more
Orthologs
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Genomic context

See SPRR3 in Genome Data Viewer
Location:
1q21.3
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (153001749..153003856)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (152138366..152140508)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (152974225..152976332)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene small proline rich protein 4 Neighboring gene small proline rich protein 1A Neighboring gene uncharacterized LOC105371446 Neighboring gene small nucleolar RNA SNORA31 Neighboring gene small proline rich protein 1B

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural molecule activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in epidermis development NAS
Non-traceable Author Statement
more info
PubMed 
involved_in keratinization IEA
Inferred from Electronic Annotation
more info
 
involved_in keratinocyte differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in peptide cross-linking IEA
Inferred from Electronic Annotation
more info
 
involved_in wound healing TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in cornified envelope TAS
Traceable Author Statement
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
small proline-rich protein 3
Names
22 kDa pancornulin
cornifin beta
esophagin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001097589.2NP_001091058.1  small proline-rich protein 3

    See identical proteins and their annotated locations for NP_001091058.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL356867, BM955458, DA763011
    Consensus CDS
    CCDS1033.1
    UniProtKB/Swiss-Prot
    Q9UBC9, Q9UDG3
    Related
    ENSP00000295367.4, ENST00000295367.5
    Conserved Domains (1) summary
    pfam02389
    Location:38167
    Cornifin; Cornifin (SPRR) family
  2. NM_005416.3NP_005407.1  small proline-rich protein 3

    See identical proteins and their annotated locations for NP_005407.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL356867, BF826427, BM955458, DA451130
    Consensus CDS
    CCDS1033.1
    UniProtKB/Swiss-Prot
    Q9UBC9, Q9UDG3
    Related
    ENSP00000330391.3, ENST00000331860.7
    Conserved Domains (1) summary
    pfam02389
    Location:38167
    Cornifin; Cornifin (SPRR) family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    153001749..153003856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    152138366..152140508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443702.1XP_047299658.1  small proline-rich protein 3 isoform X1

  2. XM_047443703.1XP_047299659.1  small proline-rich protein 3 isoform X1