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SPRR3 small proline rich protein 3 [ Homo sapiens (human) ]

Gene ID: 6707, updated on 17-Jun-2024

Summary

Official Symbol
SPRR3provided by HGNC
Official Full Name
small proline rich protein 3provided by HGNC
Primary source
HGNC:HGNC:11268
See related
Ensembl:ENSG00000163209 MIM:182271; AllianceGenome:HGNC:11268
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable structural molecule activity. Predicted to be involved in wound healing. Located in Golgi apparatus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward esophagus (RPKM 6973.3) See more
Orthologs
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Genomic context

See SPRR3 in Genome Data Viewer
Location:
1q21.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (153001749..153003856)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (152138366..152140508)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (152974225..152976332)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene small proline rich protein 4 Neighboring gene small proline rich protein 1A Neighboring gene uncharacterized LOC105371446 Neighboring gene small nucleolar RNA SNORA31 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:152995252-152996451 Neighboring gene small proline rich protein 1B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
small proline-rich protein 3
Names
22 kDa pancornulin
cornifin beta
esophagin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001097589.2NP_001091058.1  small proline-rich protein 3

    See identical proteins and their annotated locations for NP_001091058.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL356867, BM955458, DA763011
    Consensus CDS
    CCDS1033.1
    UniProtKB/Swiss-Prot
    A5YKK8, B2R4G8, D3DV32, O75597, Q4ZGI7, Q5T525, Q8NET7, Q9UBC9, Q9UDG3
    Related
    ENSP00000295367.4, ENST00000295367.5
    Conserved Domains (1) summary
    pfam02389
    Location:38167
    Cornifin; Cornifin (SPRR) family
  2. NM_005416.3NP_005407.1  small proline-rich protein 3

    See identical proteins and their annotated locations for NP_005407.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL356867, BF826427, BM955458, DA451130
    Consensus CDS
    CCDS1033.1
    UniProtKB/Swiss-Prot
    A5YKK8, B2R4G8, D3DV32, O75597, Q4ZGI7, Q5T525, Q8NET7, Q9UBC9, Q9UDG3
    Related
    ENSP00000330391.3, ENST00000331860.7
    Conserved Domains (1) summary
    pfam02389
    Location:38167
    Cornifin; Cornifin (SPRR) family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    153001749..153003856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    152138366..152140508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443702.1XP_047299658.1  small proline-rich protein 3 isoform X1

  2. XM_047443703.1XP_047299659.1  small proline-rich protein 3 isoform X1