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SPRR3 small proline rich protein 3 [ Homo sapiens (human) ]

Gene ID: 6707, updated on 12-Oct-2019

Summary

Official Symbol
SPRR3provided by HGNC
Official Full Name
small proline rich protein 3provided by HGNC
Primary source
HGNC:HGNC:11268
See related
Ensembl:ENSG00000163209 MIM:182271
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Restricted expression toward esophagus (RPKM 6973.3) See more
Orthologs

Genomic context

See SPRR3 in Genome Data Viewer
Location:
1q21.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (153001747..153003856)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (152974223..152976332)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene small proline rich protein 4 Neighboring gene small proline rich protein 1A Neighboring gene uncharacterized LOC105371446 Neighboring gene small proline rich protein 1B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Formation of the cornified envelope, organism-specific biosystem (from REACTOME)
    Formation of the cornified envelope, organism-specific biosystemAs keratinocytes progress towards the upper epidermis, they undergo a unique process of cell death termed cornification (Eckhart et al. 2013). This involves the crosslinking of keratinocyte proteins ...
  • Keratinization, organism-specific biosystem (from REACTOME)
    Keratinization, organism-specific biosystemKeratins are the major structural protein of vertebrate epidermis, constituting up to 85% of a fully differentiated keratinocyte (Fuchs 1995). Keratins belong to a superfamily of intermediate filamen...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural molecule activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cornification TAS
Traceable Author Statement
more info
 
epidermis development NAS
Non-traceable Author Statement
more info
PubMed 
keratinocyte differentiation NAS
Non-traceable Author Statement
more info
PubMed 
wound healing TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
cornified envelope TAS
Traceable Author Statement
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
small proline-rich protein 3
Names
22 kDa pancornulin
cornifin beta
esophagin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001097589.2NP_001091058.1  small proline-rich protein 3

    See identical proteins and their annotated locations for NP_001091058.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL356867, BM955458, DA763011
    Consensus CDS
    CCDS1033.1
    UniProtKB/Swiss-Prot
    Q9UBC9
    Related
    ENSP00000295367.4, ENST00000295367.5
    Conserved Domains (1) summary
    pfam02389
    Location:38167
    Cornifin; Cornifin (SPRR) family
  2. NM_005416.2NP_005407.1  small proline-rich protein 3

    See identical proteins and their annotated locations for NP_005407.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL356867, BF826427, BM955458, DA451130
    Consensus CDS
    CCDS1033.1
    UniProtKB/Swiss-Prot
    Q9UBC9
    Related
    ENSP00000330391.3, ENST00000331860.7
    Conserved Domains (1) summary
    pfam02389
    Location:38167
    Cornifin; Cornifin (SPRR) family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    153001747..153003856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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