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Romo1 reactive oxygen species modulator 1 [ Mus musculus (house mouse) ]

Gene ID: 67067, updated on 26-Sep-2022

Summary

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Official Symbol
Romo1provided by MGI
Official Full Name
reactive oxygen species modulator 1provided by MGI
Primary source
MGI:MGI:1914317
See related
Ensembl:ENSMUSG00000067847 AllianceGenome:MGI:1914317
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2010100O12Rik
Summary
Predicted to be involved in several processes, including defense response to other organism; protein targeting to mitochondrion; and replicative senescence. Located in mitochondrion. Orthologous to human ROMO1 (reactive oxygen species modulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 102.7), adrenal adult (RPKM 88.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Romo1 in Genome Data Viewer
Location:
2; 2 H1
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155986073..155987714)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (156144153..156145794)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene sperm associated antigen 4 Neighboring gene copine I Neighboring gene RNA binding motif protein 12 Neighboring gene nitrogen fixation gene 1 (S. cerevisiae) Neighboring gene RNA binding motif protein 39 Neighboring gene PHD finger protein 20

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel protein, Romo1, induces ROS production in the mitochondria. Chung YM, et al. Biochem Biophys Res Commun, 2006 Sep 1. PMID 16842742
  2. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
  
involved_in cytolysis by host of symbiont cells ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in killing of cells of another organism ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in protein insertion into mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in replicative senescence ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of TIM23 mitochondrial import inner membrane translocase complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
reactive oxygen species modulator 1
Names
ROS modulator 1
protein MGR2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164216.1 → NP_001157688.1  reactive oxygen species modulator 1

    See identical proteins and their annotated locations for NP_001157688.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AA058111, AK008300, BE996606
    Consensus CDS
    CCDS38296.1
    UniProtKB/Swiss-Prot
    P60603
    UniProtKB/TrEMBL
    A0A6P5P768, A0A8C6GFK2
    Related
    ENSMUSP00000085981.5, ENSMUST00000088610.11
    Conserved Domains (1) summary
    pfam10247
    Location:14 → 79
    Romo1; Reactive mitochondrial oxygen species modulator 1

  2. NM_001164217.2 → NP_001157689.1  reactive oxygen species modulator 1

    See identical proteins and their annotated locations for NP_001157689.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AA058111, BC028749, CJ221444
    Consensus CDS
    CCDS38296.1
    UniProtKB/Swiss-Prot
    P60603
    UniProtKB/TrEMBL
    A0A6P5P768, A0A8C6GFK2
    Related
    ENSMUSP00000113943.2, ENSMUST00000119950.2
    Conserved Domains (1) summary
    pfam10247
    Location:14 → 79
    Romo1; Reactive mitochondrial oxygen species modulator 1

  3. NM_025946.6 → NP_080222.1  reactive oxygen species modulator 1

    See identical proteins and their annotated locations for NP_080222.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC028749, EL963857
    Consensus CDS
    CCDS38296.1
    UniProtKB/Swiss-Prot
    P60603
    UniProtKB/TrEMBL
    A0A6P5P768, A0A8C6GFK2
    Related
    ENSMUSP00000105226.4, ENSMUST00000109597.10
    Conserved Domains (1) summary
    pfam10247
    Location:14 → 79
    Romo1; Reactive mitochondrial oxygen species modulator 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    155986073..155987714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60603.1 GenPept UniProtKB/Swiss-Prot:P60603

Gene LinkOut

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