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Romo1 reactive oxygen species modulator 1 [ Mus musculus (house mouse) ]

Gene ID: 67067, updated on 30-Apr-2024

Summary

Official Symbol
Romo1provided by MGI
Official Full Name
reactive oxygen species modulator 1provided by MGI
Primary source
MGI:MGI:1914317
See related
Ensembl:ENSMUSG00000067847 AllianceGenome:MGI:1914317
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2010100O12Rik
Summary
Predicted to be involved in several processes, including defense response to other organism; protein targeting to mitochondrion; and replicative senescence. Located in mitochondrion. Orthologous to human ROMO1 (reactive oxygen species modulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 102.7), adrenal adult (RPKM 88.1) and 28 other tissues See more
Orthologs
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Genomic context

See Romo1 in Genome Data Viewer
Location:
2 H1; 2 77.36 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155986073..155987714)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (156144153..156145794)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene sperm associated antigen 4 Neighboring gene copine I Neighboring gene STARR-seq mESC enhancer starr_06153 Neighboring gene STARR-positive B cell enhancer ABC_E3414 Neighboring gene RNA binding motif protein 12 Neighboring gene nitrogen fixation gene 1 (S. cerevisiae) Neighboring gene RNA binding motif protein 39 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:156005117-156005304 Neighboring gene STARR-positive B cell enhancer ABC_E817 Neighboring gene STARR-seq mESC enhancer starr_06156 Neighboring gene STARR-positive B cell enhancer ABC_E9537 Neighboring gene STARR-seq mESC enhancer starr_06157 Neighboring gene PHD finger protein 20 Neighboring gene STARR-seq mESC enhancer starr_06159 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:156104477-156104678 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:156113998-156114107

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables monoatomic cation transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
involved_in cytolysis by host of symbiont cells ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in killing of cells of another organism ISO
Inferred from Sequence Orthology
more info
 
involved_in monoatomic cation transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein insertion into mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein insertion into mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in replicative senescence ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of TIM23 mitochondrial import inner membrane translocase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of TIM23 mitochondrial import inner membrane translocase complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
reactive oxygen species modulator 1
Names
ROS modulator 1
protein MGR2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164216.1NP_001157688.1  reactive oxygen species modulator 1

    See identical proteins and their annotated locations for NP_001157688.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AA058111, AK008300, BE996606
    Consensus CDS
    CCDS38296.1
    UniProtKB/Swiss-Prot
    A2BHV9, P60603
    Related
    ENSMUSP00000085981.5, ENSMUST00000088610.11
    Conserved Domains (1) summary
    pfam10247
    Location:1479
    Romo1; Reactive mitochondrial oxygen species modulator 1
  2. NM_001164217.2NP_001157689.1  reactive oxygen species modulator 1

    See identical proteins and their annotated locations for NP_001157689.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AA058111, BC028749, CJ221444
    Consensus CDS
    CCDS38296.1
    UniProtKB/Swiss-Prot
    A2BHV9, P60603
    Related
    ENSMUSP00000113943.2, ENSMUST00000119950.2
    Conserved Domains (1) summary
    pfam10247
    Location:1479
    Romo1; Reactive mitochondrial oxygen species modulator 1
  3. NM_025946.6NP_080222.1  reactive oxygen species modulator 1

    See identical proteins and their annotated locations for NP_080222.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC028749, EL963857
    Consensus CDS
    CCDS38296.1
    UniProtKB/Swiss-Prot
    A2BHV9, P60603
    Related
    ENSMUSP00000105226.4, ENSMUST00000109597.10
    Conserved Domains (1) summary
    pfam10247
    Location:1479
    Romo1; Reactive mitochondrial oxygen species modulator 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    155986073..155987714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)