Nkap NFKB activating protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nkapprovided by MGI
Official Full Name: NFKB activating proteinprovided by MGI
Primary source: MGI:MGI:1914300
See related: Ensembl:ENSMUSG00000016409 AllianceGenome:MGI:1914300
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2610020O08Rik
Summary: Enables chromatin DNA binding activity. Acts upstream of or within hemopoiesis; negative regulation of transcription by RNA polymerase II; and stem cell population maintenance. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability. Orthologous to human NKAP (NFKB activating protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 5.4), CNS E11.5 (RPKM 5.3) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A3.3; X 21.54 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (36390416..36414399)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (37126763..37150746)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these results demonstrate the significance of NKAP-HDAC3 association in T cells.
Title: The Interaction between NKAP and HDAC3 Is Critical for T Cell Maturation.
NKAP-deficient immature peripheral T cells remain scarce in complement-deficient mice likely due to ferroptosis.
Title: Murine T Cell Maturation Entails Protection from MBL2, but Complement Proteins Do Not Drive Clearance of Cells That Fail Maturation in the Absence of NKAP.
Y352 in NKAP is critical for association with HDAC3 and for HSC maintenance and survival but is not important for proliferation of murine embryonic fibroblasts, demonstrating that NKAP functions in different complexes in different cell types.
Title: NKAP Must Associate with HDAC3 to Regulate Hematopoietic Stem Cell Maintenance and Survival.
this study shows that Treg-specific deletion of NKAP results in severe, systemic autoimmunity due to peripheral loss of Tregs
Title: Treg-specific deletion of NKAP results in severe, systemic autoimmunity due to peripheral loss of Tregs.
NKAP regulates multiple steps in Invariant NKT cell development and differentiation.
Title: NKAP Regulates Invariant NKT Cell Proliferation and Differentiation into ROR-γt-Expressing NKT17 Cells.
we provide first evidence for the expression of NKAP in neurogenic cells of the adult mammalian brain
Title: The Notch co-repressor protein NKAP is highly expressed in adult mouse subventricular zone neural progenitor cells.
Transcriptional repressor NKAP is required for invariant natural killer T cell but not conventional T cell development.
Title: The transcriptional repressor NKAP is required for the development of iNKT cells.
NKAP is required for T cell maturation and the acquisition of functional competency
Title: NKAP is required for T cell maturation and acquisition of functional competency.
Inducible deletion of NKAP in adult mice leads to lethality within 2 weeks, at which point hematopoiesis in the bone marrow has halted and hematopoietic stem cells have disappeared.
Title: Adult hematopoietic stem cells require NKAP for maintenance and survival.
NKAP functions as a transcriptional repressor, acting on Notch target genes, and is required for alphabeta T cell development.
Title: NKAP is a transcriptional repressor of notch signaling and is required for T cell development.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125507 (e-PCR)
- UniSTS:162325

AA987160 (e-PCR)
- UniSTS:166179

D20S1001 (e-PCR)
- UniSTS:154617

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within granulocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of alpha-beta T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somatic stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: NF-kappa-B-activating protein

Names: nuclear NF-kappaB activating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.