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Pus3 pseudouridine synthase 3 [ Mus musculus (house mouse) ]

Gene ID: 67049, updated on 11-Apr-2024

Summary

Official Symbol
Pus3provided by MGI
Official Full Name
pseudouridine synthase 3provided by MGI
Primary source
MGI:MGI:1914299
See related
Ensembl:ENSMUSG00000032103 AllianceGenome:MGI:1914299
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610020J05Rik; 5730412F04Rik
Summary
Enables pseudouridine synthase activity. Acts upstream of or within tRNA pseudouridine synthesis. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; heart ventricle; pharyngo-tympanic tube; pituitary gland; and vertebral axis musculature. Orthologous to human PUS3 (pseudouridine synthase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 8.0), CNS E14 (RPKM 6.4) and 23 other tissues See more
Orthologs
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Genomic context

See Pus3 in Genome Data Viewer
Location:
9 A4; 9 20.32 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (35469856..35478697)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (35558560..35567401)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene V-set and immunoglobulin domain containing 10 like 2 Neighboring gene STARR-positive B cell enhancer ABC_E11404 Neighboring gene DEAD box helicase 25 Neighboring gene HYLS1, centriolar and ciliogenesis associated Neighboring gene STARR-positive B cell enhancer ABC_E1782 Neighboring gene small cell adhesion glycoprotein family member Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables pseudouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables pseudouridine synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables pseudouridine synthase activity ISO
Inferred from Sequence Orthology
more info
 
enables tRNA pseudouridine(38/39) synthase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA modification IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in pseudouridine synthesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within tRNA pseudouridine synthesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tRNA pseudouridine synthesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
tRNA pseudouridine(38/39) synthase
Names
tRNA pseudouridine synthase 3
tRNA pseudouridylate synthase 3
tRNA-uridine isomerase 3
NP_075781.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023292.5NP_075781.3  tRNA pseudouridine(38/39) synthase

    See identical proteins and their annotated locations for NP_075781.3

    Status: VALIDATED

    Source sequence(s)
    AC118232
    Consensus CDS
    CCDS22965.1
    UniProtKB/Swiss-Prot
    Q8BVA6, Q8K0Y3, Q9JI38
    Related
    ENSMUSP00000034615.3, ENSMUST00000034615.10
    Conserved Domains (2) summary
    cd02569
    Location:68330
    PseudoU_synth_ScPus3; Pseudouridine synthase, Saccharomyces cerevisiae Pus3 like
    COG0101
    Location:66336
    TruA; tRNA U38,U39,U40 pseudouridine synthase TruA [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    35469856..35478697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)