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Higd2a HIG1 domain family, member 2A [ Mus musculus (house mouse) ]

Gene ID: 67044, updated on 30-Apr-2024

Summary

Official Symbol
Higd2aprovided by MGI
Official Full Name
HIG1 domain family, member 2Aprovided by MGI
Primary source
MGI:MGI:1914294
See related
Ensembl:ENSMUSG00000025868 AllianceGenome:MGI:1914294
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2010110M21Rik
Summary
Acts upstream of or within mitochondrial respirasome assembly. Located in mitochondrion. Is expressed in several structures, including alimentary system; eye; genitourinary system; nervous system; and skin. Orthologous to several human genes including HIGD2A (HIG1 hypoxia inducible domain family member 2A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 126.8), large intestine adult (RPKM 105.7) and 28 other tissues See more
Orthologs
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Genomic context

See Higd2a in Genome Data Viewer
Location:
13 B1; 13 28.84 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (54738044..54738960)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (54590231..54591147)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor-like 10 Neighboring gene predicted gene, 24195 Neighboring gene STARR-positive B cell enhancer ABC_E927 Neighboring gene NOP16 nucleolar protein Neighboring gene clathrin light chain B Neighboring gene STARR-seq mESC enhancer starr_34588 Neighboring gene STARR-seq mESC enhancer starr_34589 Neighboring gene STARR-seq mESC enhancer starr_34590 Neighboring gene STARR-seq mESC enhancer starr_34591 Neighboring gene Fas associated factor family member 2 Neighboring gene 4.5s RNA, pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in mitochondrial respirasome assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within mitochondrial respirasome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
HIG1 domain family member 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025933.3NP_080209.1  HIG1 domain family member 2A

    See identical proteins and their annotated locations for NP_080209.1

    Status: PROVISIONAL

    Source sequence(s)
    AC155262
    Consensus CDS
    CCDS26532.1
    UniProtKB/Swiss-Prot
    Q9CQJ1
    Related
    ENSMUSP00000026986.7, ENSMUST00000026986.7
    Conserved Domains (1) summary
    pfam04588
    Location:4796
    HIG_1_N; Hypoxia induced protein conserved region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    54738044..54738960
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)