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Rpl11 ribosomal protein L11 [ Mus musculus (house mouse) ]

Gene ID: 67025, updated on 12-May-2024

Summary

Official Symbol
Rpl11provided by MGI
Official Full Name
ribosomal protein L11provided by MGI
Primary source
MGI:MGI:1914275
See related
Ensembl:ENSMUSG00000059291 AllianceGenome:MGI:1914275
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2010203J19Rik
Summary
Predicted to enable several functions, including peroxisome proliferator activated receptor binding activity; ubiquitin ligase inhibitor activity; and ubiquitin protein ligase binding activity. Predicted to be a structural constituent of ribosome. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and protein localization to nucleus. Located in cytoplasm and nucleolus. Is expressed in cerebral cortex. Used to study Diamond-Blackfan anemia 7. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 7 and T-cell acute lymphoblastic leukemia. Orthologous to human RPL11 (ribosomal protein L11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 384.9), liver E14 (RPKM 303.0) and 28 other tissues See more
Orthologs
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Genomic context

Location:
4 D3; 4 68.34 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135776665..135780704, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (136049354..136053393, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene elongin A Neighboring gene STARR-positive B cell enhancer ABC_E2129 Neighboring gene predicted gene, 57721 Neighboring gene STARR-positive B cell enhancer ABC_E2130 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135627400-135627509 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135643248-135643431 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135644875-135644984 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135644986-135645252 Neighboring gene STARR-positive B cell enhancer ABC_E6236 Neighboring gene STARR-positive B cell enhancer ABC_E4687 Neighboring gene predicted gene, 42329 Neighboring gene inhibitor of DNA binding 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (5)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5S rRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peroxisome proliferator activated receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin ligase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein neddylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein targeting ISO
Inferred from Sequence Orthology
more info
 
involved_in rRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in ribosomal large subunit assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in ribosomal large subunit biogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
PubMed 
part_of cytosolic large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
 
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
located_in ribosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
large ribosomal subunit protein uL5
Names
60S ribosomal protein L11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025919.3NP_080195.1  large ribosomal subunit protein uL5

    See identical proteins and their annotated locations for NP_080195.1

    Status: VALIDATED

    Source sequence(s)
    AK008422, BP770399, BX530725, CA321948
    Consensus CDS
    CCDS18799.1
    UniProtKB/Swiss-Prot
    Q3TPE3, Q6ZWY0, Q9CXW4
    UniProtKB/TrEMBL
    A2BH06
    Related
    ENSMUSP00000099595.5, ENSMUST00000102536.11
    Conserved Domains (1) summary
    PTZ00156
    Location:5175
    PTZ00156; 60S ribosomal protein L11; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    135776665..135780704 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539112.3XP_006539175.1  large ribosomal subunit protein uL5 isoform X1

    UniProtKB/TrEMBL
    A2BH06
    Related
    ENSMUSP00000121108.2, ENSMUST00000155873.3
    Conserved Domains (1) summary
    PTZ00156
    Location:8178
    PTZ00156; 60S ribosomal protein L11; Provisional