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Zcchc18 zinc finger, CCHC domain containing 18 [ Mus musculus (house mouse) ]

Gene ID: 66995, updated on 24-Sep-2025
Official Symbol
Zcchc18provided by MGI
Official Full Name
zinc finger, CCHC domain containing 18provided by MGI
Primary source
MGI:MGI:1914245
See related
Ensembl:ENSMUSG00000031428 AllianceGenome:MGI:1914245
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sizn2; 1500031H04Rik
Summary
Predicted to enable zinc ion binding activity. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; glans of male genital tubercle; gut; peripheral nervous system ganglion; and sensory organ. Orthologous to human ZCCHC12 (zinc finger CCHC-type containing 12) and ZCCHC18 (zinc finger CCHC-type containing 18). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in CNS E18 (RPKM 69.4), frontal lobe adult (RPKM 40.9) and 5 other tissues See more
Orthologs
human all
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See Zcchc18 in Genome Data Viewer
Location:
X F1; X 59.1 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (135893128..135899221)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (136992379..136998472)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene thymosin beta 15b2 Neighboring gene thymosin beta 15b like Neighboring gene thymosin beta 15b1 Neighboring gene solute carrier family 25, member 53 Neighboring gene vacuolar ATPase assembly integral membrane protein Vma21 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47980 Neighboring gene family with sequence similarity 199, X-linked Neighboring gene predicted gene, 25770

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. Identification of proteins that interact with murine cytomegalovirus early protein M112-113 in brain. Wang H, et al. Chin Med J (Engl), 2011 Nov. PMID 22340173
  2. ISL1 controls pancreatic alpha cell fate and beta cell maturation. Bohuslavova R, et al. Cell Biosci, 2023 Mar 10. PMID 36899442, Free PMC Article
  3. eXPRESSION: an in silico tool to predict patterns of gene expression. Ferguson DA, et al. Gene Expr Patterns, 2005 Jun. PMID 15939374
  4. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
  5. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
zinc finger CCHC domain-containing protein 18
Names
SMAD-interacting zinc finger protein 2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035509.2 → NP_001030586.1  zinc finger CCHC domain-containing protein 18

    See identical proteins and their annotated locations for NP_001030586.1

    Status: VALIDATED

    Source sequence(s)
    AK075607, AK134856, AL672008, AL954296, AV174394, BC017627, BY261402
    Consensus CDS
    CCDS30427.1
    UniProtKB/Swiss-Prot
    Q8VD24, Q9DB17
    Related
    ENSMUSP00000098788.3, ENSMUST00000101227.3
    Conserved Domains (1) summary
    pfam14893
    Location:1 → 213
    PNMA

  2. NM_001035510.2 → NP_001030587.1  zinc finger CCHC domain-containing protein 18

    See identical proteins and their annotated locations for NP_001030587.1

    Status: VALIDATED

    Source sequence(s)
    AK075607, AK134856, AL672008, AL954296, AV174394, BY261402
    Consensus CDS
    CCDS30427.1
    UniProtKB/Swiss-Prot
    Q8VD24, Q9DB17
    Related
    ENSMUSP00000033804.5, ENSMUST00000033804.5
    Conserved Domains (1) summary
    pfam14893
    Location:1 → 213
    PNMA

  3. NM_001358437.1 → NP_001345366.1  zinc finger CCHC domain-containing protein 18

    Status: VALIDATED

    Source sequence(s)
    AK134856, AL672008, AL954296
    Consensus CDS
    CCDS30427.1
    UniProtKB/Swiss-Prot
    Q8VD24, Q9DB17
    Conserved Domains (1) summary
    pfam14893
    Location:1 → 213
    PNMA

  4. NM_001358439.1 → NP_001345368.1  zinc finger CCHC domain-containing protein 18

    Status: VALIDATED

    Source sequence(s)
    AL672008, AL954296, BY283579
    Consensus CDS
    CCDS30427.1
    UniProtKB/Swiss-Prot
    Q8VD24, Q9DB17
    Conserved Domains (1) summary
    pfam14893
    Location:1 → 213
    PNMA

  5. NM_001358440.1 → NP_001345369.1  zinc finger CCHC domain-containing protein 18

    Status: VALIDATED

    Source sequence(s)
    AL672008, AL954296
    Consensus CDS
    CCDS30427.1
    UniProtKB/Swiss-Prot
    Q8VD24, Q9DB17
    Conserved Domains (1) summary
    pfam14893
    Location:1 → 213
    PNMA

  6. NM_001358441.1 → NP_001345370.1  zinc finger CCHC domain-containing protein 18

    Status: VALIDATED

    Source sequence(s)
    AL672008, AL954296
    Consensus CDS
    CCDS30427.1
    UniProtKB/Swiss-Prot
    Q8VD24, Q9DB17
    Conserved Domains (1) summary
    pfam14893
    Location:1 → 213
    PNMA

  7. NM_025893.3 → NP_080169.2  zinc finger CCHC domain-containing protein 18

    See identical proteins and their annotated locations for NP_080169.2

    Status: VALIDATED

    Source sequence(s)
    AK005317, AK075607, AK134856, AL672008, AL954296, AV174394, BY261402
    Consensus CDS
    CCDS30427.1
    UniProtKB/Swiss-Prot
    Q8VD24, Q9DB17
    Related
    ENSMUSP00000108690.2, ENSMUST00000113067.8
    Conserved Domains (1) summary
    pfam14893
    Location:1 → 213
    PNMA

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    135893128..135899221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251484.2 → XP_030107344.1  zinc finger CCHC domain-containing protein 18 isoform X1

    UniProtKB/Swiss-Prot
    Q8VD24, Q9DB17
    Conserved Domains (1) summary
    pfam14893
    Location:1 → 213
    PNMA

  2. XM_030251485.2 → XP_030107345.1  zinc finger CCHC domain-containing protein 18 isoform X1

    UniProtKB/Swiss-Prot
    Q8VD24, Q9DB17
    Conserved Domains (1) summary
    pfam14893
    Location:1 → 213
    PNMA
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VD24.1 GenPept UniProtKB/Swiss-Prot:Q8VD24

Gene LinkOut

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