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SPRR1B small proline rich protein 1B [ Homo sapiens (human) ]

Gene ID: 6699, updated on 21-Dec-2019

Summary

Official Symbol
SPRR1Bprovided by HGNC
Official Full Name
small proline rich protein 1Bprovided by HGNC
Primary source
HGNC:HGNC:11260
See related
Ensembl:ENSG00000169469 MIM:182266
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPRR1; GADD33; SPR-IB; CORNIFIN
Summary
The protein encoded by this gene is an envelope protein of keratinocytes. The encoded protein is crosslinked to membrane proteins by transglutaminase, forming an insoluble layer under the plasma membrane. This protein is proline-rich and contains several tandem amino acid repeats. [provided by RefSeq, Nov 2015]
Expression
Restricted expression toward esophagus (RPKM 644.6) See more
Orthologs

Genomic context

See SPRR1B in Genome Data Viewer
Location:
1q21.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (153031203..153032900)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153003679..153005376)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene small proline rich protein 3 Neighboring gene uncharacterized LOC105371446 Neighboring gene small proline rich protein 2D Neighboring gene small proline rich protein 2A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC61901

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural molecule activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cornification TAS
Traceable Author Statement
more info
 
epidermis development TAS
Traceable Author Statement
more info
PubMed 
keratinocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
peptide cross-linking IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cornified envelope IDA
Inferred from Direct Assay
more info
PubMed 
cornified envelope TAS
Traceable Author Statement
more info
 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cornifin-B
Names
14.9 kDa pancornulin
small proline-rich protein IB

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003125.3NP_003116.2  cornifin-B

    See identical proteins and their annotated locations for NP_003116.2

    Status: REVIEWED

    Source sequence(s)
    BC056240, CK300778
    Consensus CDS
    CCDS30863.1
    UniProtKB/Swiss-Prot
    P22528
    Related
    ENSP00000306461.4, ENST00000307098.5
    Conserved Domains (1) summary
    pfam02389
    Location:3387
    Cornifin; Cornifin (SPRR) family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    153031203..153032900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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