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Zdhhc6 zinc finger, DHHC domain containing 6 [ Mus musculus (house mouse) ]

Gene ID: 66980, updated on 29-Jan-2023

Summary

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Official Symbol
Zdhhc6provided by MGI
Official Full Name
zinc finger, DHHC domain containing 6provided by MGI
Primary source
MGI:MGI:1914230
See related
Ensembl:ENSMUSG00000024982 AllianceGenome:MGI:1914230
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DHHC-6; 2400007G07Rik; 5930409M18Rik
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Involved in protein palmitoylation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Is expressed in several structures, including eye; genitourinary system; heart; lung epithelium; and trunk somite. Orthologous to human ZDHHC6 (zinc finger DHHC-type palmitoyltransferase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 8.6), kidney adult (RPKM 8.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zdhhc6 in Genome Data Viewer
Location:
19; 19 D2
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (55286648..55304468, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (55298216..55316036, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene guanylate cyclase 2g Neighboring gene acyl-CoA synthetase long-chain family member 5 Neighboring gene predicted gene, 31595 Neighboring gene vesicle transport through interaction with t-SNAREs 1A Neighboring gene RIKEN cDNA 4930552P12 gene Neighboring gene predicted gene, 41871

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Astrocyte Elevated Gene-1 Cys75 S-Palmitoylation by ZDHHC6 Regulates Its Biological Activity. Komaniecki G, et al. Biochemistry, 2023 Jan 17. PMID 36548985, Free PMC Article
  2. Local Palmitoylation Cycles and Specialized Membrane Domain Organization. Fukata Y, et al. Curr Top Membr, 2016. PMID 26781831
  3. Mechanistic effects of protein palmitoylation and the cellular consequences thereof. Blaskovic S, et al. Chem Phys Lipids, 2014 May. PMID 24534427
  4. Palmitoylation and the trafficking of peripheral membrane proteins. Chamberlain LH, et al. Biochem Soc Trans, 2013 Feb 1. PMID 23356259
  5. Palmitoylation and depalmitoylation dynamics at a glance. Conibear E, et al. J Cell Sci, 2010 Dec 1. PMID 21084560, Free PMC Article

See all (33) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Astrocyte Elevated Gene-1 Cys75 S-Palmitoylation by ZDHHC6 Regulates Its Biological Activity.
    Title: Astrocyte Elevated Gene-1 Cys75 S-Palmitoylation by ZDHHC6 Regulates Its Biological Activity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein-cysteine S-stearoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of mitochondrial fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein palmitoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein palmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stearoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC6
Names
H4 homolog
stearoyltransferase ZDHHC6
zinc finger DHHC domain-containing protein 6
NP_001028745.1
NP_001347524.1
NP_080159.3
XP_006527331.1
XP_011245618.1
XP_030106892.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033573.2 → NP_001028745.1  palmitoyltransferase ZDHHC6 isoform 1

    See identical proteins and their annotated locations for NP_001028745.1

    Status: VALIDATED

    Source sequence(s)
    AC133100, AK050388, AK159304, BY109555
    Consensus CDS
    CCDS29909.1
    UniProtKB/Swiss-Prot
    Q544H1, Q9CPV7
    UniProtKB/TrEMBL
    A0A8C6IHL2
    Related
    ENSMUSP00000076157.6, ENSMUST00000076891.7
    Conserved Domains (2) summary
    pfam01529
    Location:95 → 241
    DHHC; DHHC palmitoyltransferase
    pfam07653
    Location:317 → 396
    SH3_2; Variant SH3 domain

  2. NM_001360595.1 → NP_001347524.1  palmitoyltransferase ZDHHC6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC133100
    Conserved Domains (1) summary
    pfam01529
    Location:95 → 241
    zf-DHHC; DHHC palmitoyltransferase

  3. NM_025883.4 → NP_080159.3  palmitoyltransferase ZDHHC6 isoform 1

    See identical proteins and their annotated locations for NP_080159.3

    Status: VALIDATED

    Source sequence(s)
    AC133100, AK159304
    Consensus CDS
    CCDS29909.1
    UniProtKB/Swiss-Prot
    Q544H1, Q9CPV7
    UniProtKB/TrEMBL
    A0A8C6IHL2
    Related
    ENSMUSP00000153014.2, ENSMUST00000224897.2
    Conserved Domains (2) summary
    pfam01529
    Location:95 → 241
    DHHC; DHHC palmitoyltransferase
    pfam07653
    Location:317 → 396
    SH3_2; Variant SH3 domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    55286648..55304468 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247316.3 → XP_011245618.1  palmitoyltransferase ZDHHC6 isoform X1

    See identical proteins and their annotated locations for XP_011245618.1

    UniProtKB/Swiss-Prot
    Q544H1, Q9CPV7
    UniProtKB/TrEMBL
    A0A8C6IHL2
    Conserved Domains (2) summary
    pfam01529
    Location:95 → 241
    DHHC; DHHC palmitoyltransferase
    pfam07653
    Location:317 → 396
    SH3_2; Variant SH3 domain

  2. XM_006527268.4 → XP_006527331.1  palmitoyltransferase ZDHHC6 isoform X1

    See identical proteins and their annotated locations for XP_006527331.1

    UniProtKB/Swiss-Prot
    Q544H1, Q9CPV7
    UniProtKB/TrEMBL
    A0A8C6IHL2
    Conserved Domains (2) summary
    pfam01529
    Location:95 → 241
    DHHC; DHHC palmitoyltransferase
    pfam07653
    Location:317 → 396
    SH3_2; Variant SH3 domain

  3. XM_030251032.1 → XP_030106892.1  palmitoyltransferase ZDHHC6 isoform X2

    Conserved Domains (1) summary
    pfam07653
    Location:213 → 292
    SH3_2; Variant SH3 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CPV7.1 GenPept UniProtKB/Swiss-Prot:Q9CPV7

Gene LinkOut

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