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Pole4 polymerase (DNA-directed), epsilon 4 (p12 subunit) [ Mus musculus (house mouse) ]

Gene ID: 66979, updated on 8-Feb-2024

Summary

Official Symbol
Pole4provided by MGI
Official Full Name
polymerase (DNA-directed), epsilon 4 (p12 subunit)provided by MGI
Primary source
MGI:MGI:1914229
See related
Ensembl:ENSMUSG00000030042 AllianceGenome:MGI:1914229
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2400007P05Rik; 5830430F06Rik
Summary
Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be part of epsilon DNA polymerase complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and integumental system. Orthologous to human POLE4 (DNA polymerase epsilon 4, accessory subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 15.6), CNS E11.5 (RPKM 12.5) and 28 other tissues See more
Orthologs
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Genomic context

See Pole4 in Genome Data Viewer
Location:
6 C3; 6 35.94 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (82593513..82629985, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (82616532..82653043, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53289 Neighboring gene STARR-seq mESC enhancer starr_16425 Neighboring gene tachykinin receptor 1 Neighboring gene STARR-seq mESC enhancer starr_16429 Neighboring gene STARR-positive B cell enhancer ABC_E6445 Neighboring gene STARR-seq mESC enhancer starr_16430 Neighboring gene STARR-seq mESC enhancer starr_16435 Neighboring gene predicted gene, 32425 Neighboring gene predicted gene, 32534

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA-templated DNA replication ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of ATAC complex ISO
Inferred from Sequence Orthology
more info
 
part_of epsilon DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of epsilon DNA polymerase complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DNA polymerase epsilon subunit 4
Names
DNA polymerase II subunit 4
DNA polymerase epsilon subunit p12
NP_001357224.1
NP_080158.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370295.1NP_001357224.1  DNA polymerase epsilon subunit 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC159655
    Conserved Domains (1) summary
    COG5208
    Location:38113
    HAP5; CCAAT-binding factor, subunit C [Transcription]
  2. NM_025882.3NP_080158.1  DNA polymerase epsilon subunit 4 isoform 1

    See identical proteins and their annotated locations for NP_080158.1

    Status: VALIDATED

    Source sequence(s)
    AC159655
    Consensus CDS
    CCDS39524.1
    UniProtKB/Swiss-Prot
    Q3TJ13, Q9CQ36
    UniProtKB/TrEMBL
    E0CYA9
    Related
    ENSMUSP00000093462.6, ENSMUST00000095786.6
    Conserved Domains (1) summary
    cl23735
    Location:41104
    H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    82593513..82629985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003956251.2 RNA Sequence