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Slc25a23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 [ Mus musculus (house mouse) ]

Gene ID: 66972, updated on 8-Dec-2022

Summary

Official Symbol
Slc25a23provided by MGI
Official Full Name
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23provided by MGI
Primary source
MGI:MGI:1914222
See related
Ensembl:ENSMUSG00000046329 AllianceGenome:MGI:1914222
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SCaMC-3; 2310067G05Rik
Summary
Predicted to enable ATP transmembrane transporter activity. Acts upstream of or within several processes, including cellular response to calcium ion; regulation of oxidative phosphorylation; and urea homeostasis. Located in mitochondrion. Is expressed in embryo. Orthologous to human SLC25A23 (solute carrier family 25 member 23). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 76.5), cortex adult (RPKM 70.0) and 27 other tissues See more
Orthologs
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Genomic context

See Slc25a23 in Genome Data Viewer
Location:
17; 17 D
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (57350711..57366909, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (57043711..57059909, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene KH-type splicing regulatory protein Neighboring gene solute carrier family 25, member 41 Neighboring gene crumbs family member 3 Neighboring gene DENN domain containing 1C

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
calcium-binding mitochondrial carrier protein SCaMC-3
Names
small calcium-binding mitochondrial carrier protein 3
solute carrier family 25 member 23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379067.1NP_001365996.1  calcium-binding mitochondrial carrier protein SCaMC-3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT571247
    Conserved Domains (2) summary
    COG5126
    Location:7142
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    PTZ00169
    Location:189475
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
  2. NM_001379068.1NP_001365997.1  calcium-binding mitochondrial carrier protein SCaMC-3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    CT571247
    Conserved Domains (2) summary
    COG5126
    Location:7142
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    PTZ00169
    Location:189426
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
  3. NM_001379069.1NP_001365998.1  calcium-binding mitochondrial carrier protein SCaMC-3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    CT571247
    Conserved Domains (2) summary
    COG5126
    Location:7142
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    pfam00153
    Location:223316
    Mito_carr; Mitochondrial carrier protein
  4. NM_001379070.1NP_001365999.1  calcium-binding mitochondrial carrier protein SCaMC-3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    CT571247
    Conserved Domains (1) summary
    PTZ00169
    Location:66339
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
  5. NM_001412719.1NP_001399648.1  calcium-binding mitochondrial carrier protein SCaMC-3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    CT571247
  6. NM_025877.4NP_080153.2  calcium-binding mitochondrial carrier protein SCaMC-3 isoform 1

    See identical proteins and their annotated locations for NP_080153.2

    Status: VALIDATED

    Source sequence(s)
    BC017139, BC072660, CX566083
    Consensus CDS
    CCDS28923.1
    UniProtKB/Swiss-Prot
    Q6GQS1
    UniProtKB/TrEMBL
    A0A8C6HTZ7, Q9D908
    Related
    ENSMUSP00000040198.8, ENSMUST00000040280.14
    Conserved Domains (4) summary
    cd00051
    Location:84141
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    PTZ00169
    Location:189462
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:274367
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:81136
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    57350711..57366909 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246576.3XP_011244878.1  calcium-binding mitochondrial carrier protein SCaMC-3 isoform X1

    Conserved Domains (2) summary
    COG5126
    Location:7142
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    pfam00153
    Location:225325
    Mito_carr; Mitochondrial carrier protein