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Dsn1 DSN1 homolog, MIS12 kinetochore complex component [ Mus musculus (house mouse) ]

Gene ID: 66934, updated on 8-Dec-2022

Summary

Official Symbol
Dsn1provided by MGI
Official Full Name
DSN1 homolog, MIS12 kinetochore complex componentprovided by MGI
Primary source
MGI:MGI:1914184
See related
Ensembl:ENSMUSG00000027635 AllianceGenome:MGI:1914184
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700022L09Rik
Summary
Predicted to be involved in mitotic sister chromatid segregation. Predicted to act upstream of or within chromosome segregation. Predicted to be located in cytosol; kinetochore; and nuclear lumen. Predicted to be part of nuclear MIS12/MIND complex. Is expressed in several structures, including brain and retina nuclear layer. Orthologous to human DSN1 (DSN1 component of MIS12 kinetochore complex). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 10.6), CNS E11.5 (RPKM 9.4) and 20 other tissues See more
Orthologs
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Genomic context

See Dsn1 in Genome Data Viewer
Location:
2; 2 H1
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (156836982..156848995, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (156995062..157007075, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene N-myc downstream regulated gene 3 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene suppressor of glucose, autophagy associated 1 Neighboring gene TBC/LysM associated domain containing 2 Neighboring gene SAM domain and HD domain, 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of MIS12/MIND type complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of MIS12/MIND type complex ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore NAS
Non-traceable Author Statement
more info
PubMed 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
kinetochore-associated protein DSN1 homolog
Names
DSN1, MIND kinetochore complex component, homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025853.3NP_080129.2  kinetochore-associated protein DSN1 homolog

    See identical proteins and their annotated locations for NP_080129.2

    Status: VALIDATED

    Source sequence(s)
    AK006246, BC046807, CK333431
    Consensus CDS
    CCDS16972.1
    UniProtKB/Swiss-Prot
    Q9CYC5, Q9DA26
    Related
    ENSMUSP00000099418.3, ENSMUST00000103129.9
    Conserved Domains (1) summary
    pfam08202
    Location:76346
    MIS13; Mis12-Mtw1 protein family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    156836982..156848995 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)