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Rras2 related RAS viral (r-ras) oncogene 2 [ Mus musculus (house mouse) ]

Gene ID: 66922, updated on 12-May-2024

Summary

Official Symbol
Rras2provided by MGI
Official Full Name
related RAS viral (r-ras) oncogene 2provided by MGI
Primary source
MGI:MGI:1914172
See related
Ensembl:ENSMUSG00000055723 AllianceGenome:MGI:1914172
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TC21; 2610016H24Rik
Summary
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Acts upstream of or within Ras protein signal transduction and positive regulation of cell migration. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in plasma membrane. Is expressed in blood vessel; cerebral cortex; metanephros; musculature; and thymus primordium. Human ortholog(s) of this gene implicated in Noonan syndrome 12. Orthologous to human RRAS2 (RAS related 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 16.6), duodenum adult (RPKM 9.3) and 28 other tissues See more
Orthologs
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Genomic context

Location:
7 F1; 7 59.29 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (113646017..113717016, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (114046782..114117781, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5600 Neighboring gene spondin 1, (f-spondin) extracellular matrix protein Neighboring gene STARR-seq mESC enhancer starr_19921 Neighboring gene STARR-seq mESC enhancer starr_19922 Neighboring gene STARR-positive B cell enhancer ABC_E6588 Neighboring gene STARR-positive B cell enhancer ABC_E8937 Neighboring gene predicted gene, 51454 Neighboring gene STARR-positive B cell enhancer ABC_E9298 Neighboring gene predicted gene, 53365 Neighboring gene STARR-seq mESC enhancer starr_19925 Neighboring gene STARR-seq mESC enhancer starr_19926 Neighboring gene STARR-positive B cell enhancer ABC_E4966 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:121419678-121419787 Neighboring gene coatomer protein complex, subunit beta 1 Neighboring gene proteasome subunit alpha 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ras-related protein R-Ras2
Names
related RAS viral (r-ras) oncogene homolog 2
NP_080122.2
XP_017167728.1
XP_036009261.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025846.2NP_080122.2  ras-related protein R-Ras2

    See identical proteins and their annotated locations for NP_080122.2

    Status: VALIDATED

    Source sequence(s)
    AK003733, AK011419, AK078870, BX524069
    Consensus CDS
    CCDS21758.1
    UniProtKB/Swiss-Prot
    P62071, Q3TA79, Q8C5D1, Q9D0H6
    Related
    ENSMUSP00000069752.6, ENSMUST00000069449.7
    Conserved Domains (1) summary
    cd04145
    Location:13176
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    113646017..113717016 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153368.1XP_036009261.1  ras-related protein R-Ras2 isoform X1

    Conserved Domains (1) summary
    cl38936
    Location:199
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_017312239.2XP_017167728.1  ras-related protein R-Ras2 isoform X1

    Conserved Domains (1) summary
    cl38936
    Location:199
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases