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Zfp442 zinc finger protein 442 [ Mus musculus (house mouse) ]

Gene ID: 668923, updated on 9-Mar-2023

Summary

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Official Symbol
Zfp442provided by MGI
Official Full Name
zinc finger protein 442provided by MGI
Primary source
MGI:MGI:3651999
See related
Ensembl:ENSMUSG00000068130 AllianceGenome:MGI:3651999
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZIPO-II
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Zfp442 in Genome Data Viewer
Location:
2 G3; 2
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (150244400..150293421, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (150402480..150451501, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3300002I08 gene Neighboring gene predicted gene 10130 Neighboring gene predicted gene 14122 Neighboring gene methyltransferase-like protein 23 Neighboring gene zinc finger protein 345

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Clone Names

  • MGC38507

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 442
Names
zinc-finger protein in podocyte II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310645.1 → NP_001297574.1  zinc finger protein 442

    See identical proteins and their annotated locations for NP_001297574.1

    Status: VALIDATED

    Source sequence(s)
    AB470967, AL935313
    Consensus CDS
    CCDS79853.1
    UniProtKB/TrEMBL
    A2AQA0
    Related
    ENSMUSP00000105542.2, ENSMUST00000109916.8
    Conserved Domains (5) summary
    smart00349
    Location:4 → 57
    KRAB; krueppel associated box
    COG5048
    Location:209 → 589
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:213 → 233
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:225 → 250
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    150244400..150293421 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239742.4 → XP_011238044.1  zinc finger protein 442 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:177 → 557
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:539 → 622
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:181 → 201
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_011239741.2 → XP_011238043.1  zinc finger protein 442 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:215 → 595
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:577 → 660
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:219 → 239
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:10 → 50
    KRAB; KRAB box

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001177550.1: Suppressed sequence

    Description
    NM_001177550.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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