Mrgpra9 MAS-related GPR, member A9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mrgpra9provided by MGI
Official Full Name: MAS-related GPR, member A9provided by MGI
Primary source: MGI:MGI:3033148
See related: Ensembl:ENSMUSG00000074111 AllianceGenome:MGI:3033148
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MrgA9; mAde2R; EG668725
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Orthologous to human MRGPRX2 (MAS related GPR family member X2); MRGPRX3 (MAS related GPR family member X3); and MRGPRX4 (MAS related GPR family member X4). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 7 B3; 7 30.76 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (46884667..46902627, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (47234919..47252879, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We now describe the cloning and characterization of two new members of the Adenine receptor family from mouse (MrgA10, termed mAde1R) and hamster (cAdeR).
Title: Characterization of new G protein-coupled adenine receptors in mouse and hamster.
A second mammalian DNA sequence encodes for a G(i) protein-coupled receptor activated by low, nanomolar concentrations of adenine.
Title: Cloning and functional expression of a novel Gi protein-coupled receptor for adenine from mouse brain.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: uncharacterized protein LOC668725

Names: G-protein coupled adenine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001288801.2 → NP_001275730.1 uncharacterized protein LOC668725

Status: VALIDATED

Source sequence(s)

AC115898, AC163020

Consensus CDS

CCDS57550.2

UniProtKB/TrEMBL

A0A140T8U8, L7N225

Related

ENSMUSP00000136396.3, ENSMUST00000179005.3

Conserved Domains (1) summary

pfam00001
Location:57 → 289

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

46884667..46902627 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001177566.1: Suppressed sequence

Description

NM_001177566.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.