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Mfsd1 major facilitator superfamily domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 66868, updated on 12-May-2024

Summary

Official Symbol
Mfsd1provided by MGI
Official Full Name
major facilitator superfamily domain containing 1provided by MGI
Primary source
MGI:MGI:1914118
See related
Ensembl:ENSMUSG00000027775 AllianceGenome:MGI:1914118
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1200003O06Rik
Summary
Enables protein homodimerization activity. Involved in protein localization to lysosome and protein stabilization. Located in lysosome. Is expressed in embryo. Orthologous to human MFSD1 (major facilitator superfamily domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 75.5), placenta adult (RPKM 43.9) and 27 other tissues See more
Orthologs
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Genomic context

See Mfsd1 in Genome Data Viewer
Location:
3 E1; 3 31.07 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (67490101..67511564)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (67582768..67604231)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35299 Neighboring gene STARR-seq mESC enhancer starr_07890 Neighboring gene STARR-seq mESC enhancer starr_07891 Neighboring gene STARR-positive B cell enhancer ABC_E8801 Neighboring gene STARR-positive B cell enhancer ABC_E11190 Neighboring gene predicted gene, 25919 Neighboring gene STARR-positive B cell enhancer ABC_E4547 Neighboring gene STARR-seq mESC enhancer starr_07892 Neighboring gene chromatin modifying protein 1A pseudogene Neighboring gene pyrimidinergic receptor P2Y, G-protein coupled, 4 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein localization to lysosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
major facilitator superfamily domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025813.3NP_080089.1  major facilitator superfamily domain-containing protein 1

    See identical proteins and their annotated locations for NP_080089.1

    Status: VALIDATED

    Source sequence(s)
    AC135635
    Consensus CDS
    CCDS38450.1
    UniProtKB/Swiss-Prot
    Q3UWU0, Q8BVZ3, Q9DC37
    Related
    ENSMUSP00000029344.9, ENSMUST00000029344.10
    Conserved Domains (2) summary
    cd06174
    Location:45438
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:48402
    MFS_1; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    67490101..67511564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)