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Hmg20a high mobility group 20A [ Mus musculus (house mouse) ]

Gene ID: 66867, updated on 3-Jan-2023

Summary

Official Symbol
Hmg20aprovided by MGI
Official Full Name
high mobility group 20Aprovided by MGI
Primary source
MGI:MGI:1914117
See related
Ensembl:ENSMUSG00000032329 AllianceGenome:MGI:1914117
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ibraf; Hmgxb1; 1200004E06Rik; 5730490E10Rik
Summary
Predicted to enable identical protein binding activity. Acts upstream of or within negative regulation of neuron differentiation; negative regulation of protein sumoylation; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including axial skeleton; early conceptus; genitourinary system; gut; and nervous system. Orthologous to human HMG20A (high mobility group 20A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 21.5), whole brain E14.5 (RPKM 21.1) and 28 other tissues See more
Orthologs
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Genomic context

See Hmg20a in Genome Data Viewer
Location:
9; 9 B
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (56325891..56404220)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (56418619..56496936)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene tetraspanin 3 Neighboring gene pseudopodium-enriched atypical kinase 1 Neighboring gene pseudopodium-enriched atypical kinase 1, opposite strand Neighboring gene ubiquitin-conjugating enzyme E2S pseudogene Neighboring gene predicted gene, 53524 Neighboring gene predicted gene, 31529

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
high mobility group protein 20A
Names
HMG box-containing protein 20A
HMG domain-containing protein HMGX1
inhibitor of BRAF35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025812.3NP_080088.1  high mobility group protein 20A

    See identical proteins and their annotated locations for NP_080088.1

    Status: VALIDATED

    Source sequence(s)
    AC159819
    Consensus CDS
    CCDS23208.1
    UniProtKB/Swiss-Prot
    Q9CYG2, Q9DC33
    UniProtKB/TrEMBL
    A0A8C6GRM7
    Related
    ENSMUSP00000034879.4, ENSMUST00000034879.5
    Conserved Domains (2) summary
    cd01390
    Location:102167
    HMGB-UBF_HMG-box; class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal ...
    pfam17380
    Location:76312
    DUF5401; Family of unknown function (DUF5401)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    56325891..56404220
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155195.1XP_036011088.1  high mobility group protein 20A isoform X1

    UniProtKB/Swiss-Prot
    Q9CYG2
    UniProtKB/TrEMBL
    A0A8C6GRM7
    Conserved Domains (2) summary
    cd01390
    Location:102167
    HMGB-UBF_HMG-box; class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal ...
    pfam17380
    Location:76312
    DUF5401; Family of unknown function (DUF5401)