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Tanc1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 [ Mus musculus (house mouse) ]

Gene ID: 66860, updated on 26-Sep-2022

Summary

Official Symbol
Tanc1provided by MGI
Official Full Name
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1provided by MGI
Primary source
MGI:MGI:1914110
See related
Ensembl:ENSMUSG00000035168 AllianceGenome:MGI:1914110
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tanc; mKIAA1728; 1200003E16Rik
Summary
Acts upstream of or within dendritic spine maintenance; myoblast fusion; and visual learning. Located in axon terminus; dendrite; and neuronal cell body. Is expressed in mandible; maxilla; metanephros; olfactory cortex ventricular layer; and telencephalon ventricular layer. Orthologous to human TANC1 (tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 4.4), lung adult (RPKM 3.7) and 28 other tissues See more
Orthologs
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Genomic context

See Tanc1 in Genome Data Viewer
Location:
2; 2 C1.1
Exon count:
33
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (59442167..59676557)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (59611821..59846213)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm717 Neighboring gene mitochondrial ribosomal protein S18B pseudogene Neighboring gene predicted gene, 53240 Neighboring gene VISTA enhancer mm282 Neighboring gene WD repeat, SAM and U-box domain containing 1 Neighboring gene predicted gene, 52554 Neighboring gene bromodomain adjacent to zinc finger domain, 2B Neighboring gene predicted gene 13572

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within dendritic spine maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myoblast fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of postsynapse organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of postsynapse organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in axon terminus IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density, intracellular component ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein TANC1
Names
TPR domain, ankyrin-repeat and coiled-coil-containing protein
tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290659.1NP_001277588.1  protein TANC1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a. The 5' UTR of this variant is incomplete due to a lack of full-length transcript support and splice pattern ambiguity in the upstream region.
    Source sequence(s)
    AK031162, AK079966, BC079914, BY753173, CX769146
    Consensus CDS
    CCDS71057.1
    UniProtKB/Swiss-Prot
    Q0VGY8
    UniProtKB/TrEMBL
    E9QAF9
    Conserved Domains (5) summary
    PHA03095
    Location:8961208
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:12751406
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:12821307
    TPR; TPR repeat [structural motif]
    sd00045
    Location:11351165
    ANK; ANK repeat [structural motif]
    cl39094
    Location:10821306
    Ank_2; Ankyrin repeats (3 copies)
  2. NM_198294.3NP_938036.2  protein TANC1 isoform a

    See identical proteins and their annotated locations for NP_938036.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). The 5'-most non-coding exon of this variant is inferred based on partial transcript alignments.
    Source sequence(s)
    AK031162, AK079966, BC079914, BY753173, CX769146
    Consensus CDS
    CCDS16054.1
    UniProtKB/Swiss-Prot
    Q0VGY8, Q8C0Q6
    Related
    ENSMUSP00000036003.5, ENSMUST00000037526.11
    Conserved Domains (5) summary
    PHA03095
    Location:9031215
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:12821413
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:12891314
    TPR; TPR repeat [structural motif]
    sd00045
    Location:11421172
    ANK; ANK repeat [structural motif]
    cl39094
    Location:10891313
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    59442167..59676557
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319203.3XP_017174692.1  protein TANC1 isoform X1

    Conserved Domains (6) summary
    PHA03095
    Location:9211233
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:13001431
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:13071332
    TPR; TPR repeat [structural motif]
    sd00045
    Location:11601190
    ANK; ANK repeat [structural motif]
    pfam09606
    Location:15101802
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl39094
    Location:11071331
    Ank_2; Ankyrin repeats (3 copies)
  2. XM_030251967.1XP_030107827.1  protein TANC1 isoform X4

    UniProtKB/TrEMBL
    E9QAF9
    Conserved Domains (5) summary
    PHA03095
    Location:8961208
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:12751406
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:12821307
    TPR; TPR repeat [structural motif]
    sd00045
    Location:11351165
    ANK; ANK repeat [structural motif]
    cl39094
    Location:10821306
    Ank_2; Ankyrin repeats (3 copies)
  3. XM_017319205.3XP_017174694.1  protein TANC1 isoform X4

    UniProtKB/TrEMBL
    E9QAF9
    Related
    ENSMUSP00000108187.2, ENSMUST00000112568.8
    Conserved Domains (5) summary
    PHA03095
    Location:8961208
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:12751406
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:12821307
    TPR; TPR repeat [structural motif]
    sd00045
    Location:11351165
    ANK; ANK repeat [structural motif]
    cl39094
    Location:10821306
    Ank_2; Ankyrin repeats (3 copies)
  4. XM_036162490.1XP_036018383.1  protein TANC1 isoform X3

    UniProtKB/Swiss-Prot
    Q8C0Q6
    Related
    ENSMUSP00000123345.3, ENSMUST00000139863.3
    Conserved Domains (5) summary
    PHA03095
    Location:9031215
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:12821413
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:12891314
    TPR; TPR repeat [structural motif]
    sd00045
    Location:11421172
    ANK; ANK repeat [structural motif]
    cl39094
    Location:10891313
    Ank_2; Ankyrin repeats (3 copies)
  5. XM_006500034.5XP_006500097.1  protein TANC1 isoform X1

    See identical proteins and their annotated locations for XP_006500097.1

    Conserved Domains (6) summary
    PHA03095
    Location:9211233
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:13001431
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:13071332
    TPR; TPR repeat [structural motif]
    sd00045
    Location:11601190
    ANK; ANK repeat [structural motif]
    pfam09606
    Location:15101802
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl39094
    Location:11071331
    Ank_2; Ankyrin repeats (3 copies)
  6. XM_017319200.3XP_017174689.1  protein TANC1 isoform X1

    Conserved Domains (6) summary
    PHA03095
    Location:9211233
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:13001431
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:13071332
    TPR; TPR repeat [structural motif]
    sd00045
    Location:11601190
    ANK; ANK repeat [structural motif]
    pfam09606
    Location:15101802
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl39094
    Location:11071331
    Ank_2; Ankyrin repeats (3 copies)
  7. XM_030251966.2XP_030107826.1  protein TANC1 isoform X1

    Conserved Domains (6) summary
    PHA03095
    Location:9211233
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:13001431
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:13071332
    TPR; TPR repeat [structural motif]
    sd00045
    Location:11601190
    ANK; ANK repeat [structural motif]
    pfam09606
    Location:15101802
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl39094
    Location:11071331
    Ank_2; Ankyrin repeats (3 copies)
  8. XM_036162489.1XP_036018382.1  protein TANC1 isoform X3

    UniProtKB/Swiss-Prot
    Q8C0Q6
    Conserved Domains (5) summary
    PHA03095
    Location:9031215
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:12821413
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:12891314
    TPR; TPR repeat [structural motif]
    sd00045
    Location:11421172
    ANK; ANK repeat [structural motif]
    cl39094
    Location:10891313
    Ank_2; Ankyrin repeats (3 copies)
  9. XM_036162492.1XP_036018385.1  protein TANC1 isoform X4

    UniProtKB/TrEMBL
    E9QAF9
    Conserved Domains (5) summary
    PHA03095
    Location:8961208
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:12751406
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:12821307
    TPR; TPR repeat [structural motif]
    sd00045
    Location:11351165
    ANK; ANK repeat [structural motif]
    cl39094
    Location:10821306
    Ank_2; Ankyrin repeats (3 copies)
  10. XM_006500037.5XP_006500100.1  protein TANC1 isoform X2

    Conserved Domains (6) summary
    PHA03095
    Location:9141226
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:12931424
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:13001325
    TPR; TPR repeat [structural motif]
    sd00045
    Location:11531183
    ANK; ANK repeat [structural motif]
    pfam09606
    Location:15031795
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl39094
    Location:11001324
    Ank_2; Ankyrin repeats (3 copies)
  11. XM_017319204.3XP_017174693.1  protein TANC1 isoform X1

    Conserved Domains (6) summary
    PHA03095
    Location:9211233
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:13001431
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:13071332
    TPR; TPR repeat [structural motif]
    sd00045
    Location:11601190
    ANK; ANK repeat [structural motif]
    pfam09606
    Location:15101802
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl39094
    Location:11071331
    Ank_2; Ankyrin repeats (3 copies)
  12. XM_036162491.1XP_036018384.1  protein TANC1 isoform X4

    UniProtKB/TrEMBL
    E9QAF9
    Conserved Domains (5) summary
    PHA03095
    Location:8961208
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:12751406
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:12821307
    TPR; TPR repeat [structural motif]
    sd00045
    Location:11351165
    ANK; ANK repeat [structural motif]
    cl39094
    Location:10821306
    Ank_2; Ankyrin repeats (3 copies)
  13. XM_017319202.3XP_017174691.1  protein TANC1 isoform X1

    Conserved Domains (6) summary
    PHA03095
    Location:9211233
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:13001431
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:13071332
    TPR; TPR repeat [structural motif]
    sd00045
    Location:11601190
    ANK; ANK repeat [structural motif]
    pfam09606
    Location:15101802
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl39094
    Location:11071331
    Ank_2; Ankyrin repeats (3 copies)
  14. XM_006500036.5XP_006500099.1  protein TANC1 isoform X1

    See identical proteins and their annotated locations for XP_006500099.1

    Conserved Domains (6) summary
    PHA03095
    Location:9211233
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:13001431
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:13071332
    TPR; TPR repeat [structural motif]
    sd00045
    Location:11601190
    ANK; ANK repeat [structural motif]
    pfam09606
    Location:15101802
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl39094
    Location:11071331
    Ank_2; Ankyrin repeats (3 copies)
  15. XM_006500039.3XP_006500102.1  protein TANC1 isoform X5

    Conserved Domains (6) summary
    PHA03095
    Location:7031015
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:10821213
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:10891114
    TPR; TPR repeat [structural motif]
    sd00045
    Location:942972
    ANK; ANK repeat [structural motif]
    pfam09606
    Location:12921584
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl39094
    Location:8891113
    Ank_2; Ankyrin repeats (3 copies)
  16. XM_006500040.5XP_006500103.1  protein TANC1 isoform X6

    Conserved Domains (6) summary
    PHA03095
    Location:599911
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:9781109
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:9851010
    TPR; TPR repeat [structural motif]
    sd00045
    Location:838868
    ANK; ANK repeat [structural motif]
    pfam09606
    Location:11881480
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl39094
    Location:7851009
    Ank_2; Ankyrin repeats (3 copies)