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Hint3 histidine triad nucleotide binding protein 3 [ Mus musculus (house mouse) ]

Gene ID: 66847, updated on 5-Mar-2024

Summary

Official Symbol
Hint3provided by MGI
Official Full Name
histidine triad nucleotide binding protein 3provided by MGI
Primary source
MGI:MGI:1914097
See related
Ensembl:ENSMUSG00000019791 AllianceGenome:MGI:1914097
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HINT4; HINT-3; HINT-4; 0610010I17Rik
Summary
Predicted to enable adenosine 5'-monophosphoramidase activity and identical protein binding activity. Predicted to be located in cytoplasm and nucleus. Is expressed in embryo. Orthologous to human HINT3 (histidine triad nucleotide binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 4.5), heart adult (RPKM 4.3) and 28 other tissues See more
Orthologs
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Genomic context

See Hint3 in Genome Data Viewer
Location:
10 A4; 10 17.1 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (30479191..30499526, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (30603195..30623530, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22623 Neighboring gene tRNA methyltransferase 11 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:30320514-30320623 Neighboring gene STARR-positive B cell enhancer ABC_E6828 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:30338273-30338456 Neighboring gene predicted gene, 20300 Neighboring gene STARR-seq mESC enhancer starr_26197 Neighboring gene STARR-seq mESC enhancer starr_26199 Neighboring gene nuclear receptor coactivator 7 Neighboring gene STARR-seq mESC enhancer starr_26200 Neighboring gene STARR-positive B cell enhancer ABC_E5123 Neighboring gene STARR-seq mESC enhancer starr_26202 Neighboring gene STARR-positive B cell enhancer ABC_E8861 Neighboring gene non-POU-domain-containing, octamer binding protein pseudogene Neighboring gene nuclear encoded tRNA glutamic acid 9 (anticodon CTC)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables adenosine 5'-monophosphoramidase activity ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
adenosine 5'-monophosphoramidase HINT3
Names
histidine triad protein 4
NP_080074.1
XP_006512886.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025798.3NP_080074.1  adenosine 5'-monophosphoramidase HINT3

    See identical proteins and their annotated locations for NP_080074.1

    Status: PROVISIONAL

    Source sequence(s)
    AK027974
    Consensus CDS
    CCDS23764.1
    UniProtKB/Swiss-Prot
    Q9CPS6
    UniProtKB/TrEMBL
    F8WH96
    Related
    ENSMUSP00000125552.2, ENSMUST00000161074.8
    Conserved Domains (1) summary
    cd01278
    Location:30133
    aprataxin_related; aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    30479191..30499526 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512823.3XP_006512886.1  adenosine 5'-monophosphoramidase HINT3 isoform X1

    Conserved Domains (1) summary
    cd01278
    Location:30168
    aprataxin_related; aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are ...