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Dele1 DAP3 binding cell death enhancer 1 [ Mus musculus (house mouse) ]

Gene ID: 66839, updated on 30-Apr-2024

Summary

Official Symbol
Dele1provided by MGI
Official Full Name
DAP3 binding cell death enhancer 1provided by MGI
Primary source
MGI:MGI:1914089
See related
Ensembl:ENSMUSG00000024442 AllianceGenome:MGI:1914089
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dele; DELE1(L); Kiaa0141; 0610009O20Rik; 2700004E22Rik
Summary
Predicted to enable protein kinase binding activity and protein serine/threonine kinase activator activity. Predicted to be involved in HRI-mediated signaling; extrinsic apoptotic signaling pathway via death domain receptors; and regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to act upstream of or within apoptotic process. Located in mitochondrion. Orthologous to human DELE1 (DAP3 binding cell death enhancer 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 66.6), adrenal adult (RPKM 62.6) and 28 other tissues See more
Orthologs
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Genomic context

See Dele1 in Genome Data Viewer
Location:
18 B3; 18 20.15 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (38383302..38395682)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (38250249..38262629)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2010320O07 gene Neighboring gene RIKEN cDNA 1700086O06 gene Neighboring gene 60S ribosomal protein L17-like Neighboring gene STARR-positive B cell enhancer ABC_E7580 Neighboring gene STARR-seq mESC enhancer starr_44353 Neighboring gene protocadherin 12 Neighboring gene ring finger protein 14 Neighboring gene STARR-seq mESC enhancer starr_44354 Neighboring gene predicted gene, 23205

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DAP3-binding cell death enhancer 1
Names
DAP3-binding cell death enhancer 1, long form
death ligand signal enhancer

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024179.5NP_077141.2  DAP3-binding cell death enhancer 1

    See identical proteins and their annotated locations for NP_077141.2

    Status: VALIDATED

    Source sequence(s)
    AK002437, AK009400, AU257559, BY193394
    Consensus CDS
    CCDS50260.1
    UniProtKB/Swiss-Prot
    Q6A0B8, Q9DCV6
    UniProtKB/TrEMBL
    Q3TAH8
    Related
    ENSMUSP00000025314.6, ENSMUST00000025314.7
    Conserved Domains (3) summary
    smart00671
    Location:278313
    SEL1; Sel1-like repeats
    COG0790
    Location:175431
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:261290
    SLR; SLR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    38383302..38395682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)