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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_008730.1 RefSeqGene
- Range
-
5001..99027
- Download
- GenBank, FASTA, Sequence Viewer (Graphics), LRG_714
mRNA and Protein(s)
-
NM_001363823.2 → NP_001350752.1 spastin isoform 3
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, which results in a shorter isoform (3), compared to isoform 1. This variant is also predicted to use an alternate, in-frame, downstream translation initiation site to encode an even shorter isoform.
- Source sequence(s)
-
AL121655, AL121658
- Related
- ENSP00000482496.2, ENST00000621856.2
- Conserved Domains (2) summary
-
- COG0464
Location:310 → 596
- SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
- cd02679
Location:116 → 194
- MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
-
NM_001363875.2 → NP_001350804.1 spastin isoform 4
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) has multiple differences in the coding region, compared to variant 1. It encodes a shorter isoform (4), compared to isoform 1. This variant is also predicted to use an alternate, in-frame, downstream translation initiation site to encode an even shorter isoform.
- Source sequence(s)
-
AL121655, AL121658
- Consensus CDS
-
CCDS86830.1
- Related
- ENSP00000493827.1, ENST00000642455.1
- Conserved Domains (2) summary
-
- COG0464
Location:278 → 564
- SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
- cd02679
Location:116 → 194
- MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
-
NM_001377959.1 → NP_001364888.1 spastin isoform 5
Status: REVIEWED
- Source sequence(s)
-
AL121655, AL121658
- Related
- ENSP00000495478.1, ENST00000642751.1
-
NM_014946.4 → NP_055761.2 spastin isoform 1
See identical proteins and their annotated locations for NP_055761.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1; also known as M1). It also encodes a shorter isoform (M87) from an alternate, in-frame, downstream translation initiation site.
- Source sequence(s)
-
AJ246001, AL121655, AL121658
- Consensus CDS
-
CCDS1778.1
- UniProtKB/Swiss-Prot
-
Q9UBP0
- UniProtKB/TrEMBL
-
E5KRP5
- Related
- ENSP00000320885.3, ENST00000315285.8
- Conserved Domains (2) summary
-
- COG0464
Location:311 → 597
- SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
- cd02679
Location:116 → 195
- MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
-
NM_199436.2 → NP_955468.1 spastin isoform 2
See identical proteins and their annotated locations for NP_955468.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (2), compared to isoform 1. This variant is also predicted to use an alternate, in-frame, downstream translation initiation site to encode an even shorter isoform.
- Source sequence(s)
-
AL121655, AL121658, BC150260
- Consensus CDS
-
CCDS1779.1
- UniProtKB/Swiss-Prot
-
Q9UBP0
- UniProtKB/TrEMBL
-
E5KRP6
- Related
- ENSP00000495015.1, ENST00000646571.1
- Conserved Domains (2) summary
-
- COG0464
Location:279 → 565
- SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
- cd02679
Location:116 → 195
- MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p13 Primary Assembly
Genomic
-
NC_000002.12 Reference GRCh38.p13 Primary Assembly
- Range
-
32063551..32157637
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_011533067.2 → XP_011531369.1 spastin isoform X3
See identical proteins and their annotated locations for XP_011531369.1
- Conserved Domains (2) summary
-
- COG0464
Location:311 → 547
- SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
- cd02679
Location:116 → 195
- MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...