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Duoxa2 dual oxidase maturation factor 2 [ Mus musculus (house mouse) ]

Gene ID: 66811, updated on 12-Apr-2023


Official Symbol
Duoxa2provided by MGI
Official Full Name
dual oxidase maturation factor 2provided by MGI
Primary source
See related
Ensembl:ENSMUSG00000027225 AllianceGenome:MGI:1914061
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nip2; 9030623N16Rik
Predicted to enable enzyme binding activity. Acts upstream of or within hydrogen peroxide metabolic process; regulation of inflammatory response; and regulation of thyroid hormone generation. Predicted to be located in several cellular components, including apical part of cell; cell leading edge; and endoplasmic reticulum. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in thyroid dyshormonogenesis 5. Orthologous to human DUOXA2 (dual oxidase maturation factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Biased expression in large intestine adult (RPKM 124.2), stomach adult (RPKM 98.7) and 2 other tissues See more
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Genomic context

See Duoxa2 in Genome Data Viewer
2; 2 E5
Exon count:
Annotation release Status Assembly Chr Location
RS_2023_04 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (122129381..122133088)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (122298900..122302885)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene sorbitol dehydrogenase Neighboring gene dual oxidase 2 Neighboring gene dual oxidase maturation factor 1 Neighboring gene dual oxidase 1 Neighboring gene Src homology 2 domain containing F

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a



Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
located_in cytosol ISO
Inferred from Sequence Orthology
more info
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info

General protein information

Preferred Names
dual oxidase maturation factor 2
Numb-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025777.3NP_080053.1  dual oxidase maturation factor 2

    See identical proteins and their annotated locations for NP_080053.1

    Status: VALIDATED

    Source sequence(s)
    Consensus CDS
    Q9D311, Q9D7U8
    ENSMUSP00000028656.2, ENSMUST00000028656.2
    Conserved Domains (1) summary
    DuoxA; Dual oxidase maturation factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000068.8 Reference GRCm39 C57BL/6J

    GenBank, FASTA, Sequence Viewer (Graphics)