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Rbm22 RNA binding motif protein 22 [ Mus musculus (house mouse) ]

Gene ID: 66810, updated on 8-Feb-2024

Summary

Official Symbol
Rbm22provided by MGI
Official Full Name
RNA binding motif protein 22provided by MGI
Primary source
MGI:MGI:1914060
See related
Ensembl:ENSMUSG00000024604 AllianceGenome:MGI:1914060
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
8430430L24Rik
Summary
Predicted to enable U6 snRNA binding activity; calcium-dependent protein binding activity; and pre-mRNA binding activity. Predicted to be involved in several processes, including mRNA cis splicing, via spliceosome; positive regulation of RNA splicing; and positive regulation of nucleocytoplasmic transport. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of Prp19 complex; U2-type catalytic step 1 spliceosome; and U2-type catalytic step 2 spliceosome. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human RBM22 (RNA binding motif protein 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 18.7), CNS E14 (RPKM 17.4) and 28 other tissues See more
Orthologs
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Genomic context

See Rbm22 in Genome Data Viewer
Location:
18 D3; 18 34.36 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (60693858..60705801)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (60560786..60572729)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46628 Neighboring gene dynactin 4 Neighboring gene STARR-positive B cell enhancer ABC_E9978 Neighboring gene predicted gene, 52358 Neighboring gene myozenin 3 Neighboring gene synaptopodin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC91134

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables U6 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables U6 snRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables pre-mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables pre-mRNA binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Prp19 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of U2-type catalytic step 1 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of U2-type catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of U2-type catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pre-mRNA-splicing factor RBM22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025776.2NP_080052.1  pre-mRNA-splicing factor RBM22

    See identical proteins and their annotated locations for NP_080052.1

    Status: PROVISIONAL

    Source sequence(s)
    AK168919
    Consensus CDS
    CCDS29272.1
    UniProtKB/Swiss-Prot
    Q3TJB0, Q8BHS3, Q9CXA0
    Related
    ENSMUSP00000025506.7, ENSMUST00000025506.7
    Conserved Domains (2) summary
    smart00356
    Location:159185
    ZnF_C3H1; zinc finger
    cd12224
    Location:231304
    RRM_RBM22; RNA recognition motif (RRM) found in Pre-mRNA-splicing factor RBM22 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    60693858..60705801
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)