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Atg10 autophagy related 10 [ Mus musculus (house mouse) ]

Gene ID: 66795, updated on 3-Apr-2024

Summary

Official Symbol
Atg10provided by MGI
Official Full Name
autophagy related 10provided by MGI
Primary source
MGI:MGI:1914045
See related
Ensembl:ENSMUSG00000021619 AllianceGenome:MGI:1914045
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
APG10; Agp10; Apg10l; Apg10p; Atg10l; mAPG10; 5330424L23Rik; 5430428K15Rik
Summary
Enables Atg12 conjugating enzyme activity. Acts upstream of or within positive regulation of protein modification process and protein lipidation. Predicted to be located in cytosol. Orthologous to human ATG10 (autophagy related 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 1.2), heart adult (RPKM 0.9) and 25 other tissues See more
Orthologs
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Genomic context

See Atg10 in Genome Data Viewer
Location:
13 C3; 13 46.46 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (91083467..91372189, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (90935348..91224725, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ATPase, H+ transporting, lysosomal accessory protein 1-like Neighboring gene STARR-positive B cell enhancer ABC_E3091 Neighboring gene ribosomal protein S23 Neighboring gene STARR-seq mESC enhancer starr_35246 Neighboring gene STARR-seq mESC enhancer starr_35249 Neighboring gene STARR-seq mESC enhancer starr_35250 Neighboring gene 40S ribosomal protein S14 pseudogene Neighboring gene predicted gene, 41014 Neighboring gene heterogeneous nuclear ribonucleoprotein K pseudogene Neighboring gene RIKEN cDNA A830009L08 gene Neighboring gene STARR-seq mESC enhancer starr_35251 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:91510584-91510802

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Atg12 conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables Atg12 conjugating enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
enables Atg12 conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
 
enables Atg12 transferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables Atg12 transferase activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-like protein transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in ER overload response ISO
Inferred from Sequence Orthology
more info
 
involved_in autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of protein modification process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein lipidation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein lipidation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein modification by small protein conjugation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein modification by small protein conjugation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ubiquitin-like-conjugating enzyme ATG10
Names
autophagy-related protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001404917.1NP_001391846.1  ubiquitin-like-conjugating enzyme ATG10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC108947, AC134461, AC160980
    UniProtKB/TrEMBL
    A0A0R4J029
  2. NM_001404918.1NP_001391847.1  ubiquitin-like-conjugating enzyme ATG10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC108947, AC134461, AC160980
    UniProtKB/TrEMBL
    A0A0R4J029
  3. NM_001404919.1NP_001391848.1  ubiquitin-like-conjugating enzyme ATG10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC108947, AC134461, AC160980
    UniProtKB/TrEMBL
    A0A0R4J029
  4. NM_001404920.1NP_001391849.1  ubiquitin-like-conjugating enzyme ATG10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC108947, AC134461, AC160980
    UniProtKB/TrEMBL
    A0A0R4J029
  5. NM_001404921.1NP_001391850.1  ubiquitin-like-conjugating enzyme ATG10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC108947, AC134461, AC160980
  6. NM_001404922.1NP_001391851.1  ubiquitin-like-conjugating enzyme ATG10 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC108947, AC134461, AC160980
  7. NM_001404923.1NP_001391852.1  ubiquitin-like-conjugating enzyme ATG10 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC108947, AC134461, AC160980
  8. NM_001404925.1NP_001391854.1  ubiquitin-like-conjugating enzyme ATG10 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC108947, AC134461, AC160980
  9. NM_001404926.1NP_001391855.1  ubiquitin-like-conjugating enzyme ATG10 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC108947, AC134461, AC160980
  10. NM_001404927.1NP_001391856.1  ubiquitin-like-conjugating enzyme ATG10 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC108947, AC134461, AC160980
  11. NM_001404928.1NP_001391857.1  ubiquitin-like-conjugating enzyme ATG10 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC108947, AC160980
  12. NM_025770.4NP_080046.3  ubiquitin-like-conjugating enzyme ATG10 isoform 1

    See identical proteins and their annotated locations for NP_080046.3

    Status: VALIDATED

    Source sequence(s)
    AC108947, AC134461, AC160980
    Consensus CDS
    CCDS26675.1
    UniProtKB/Swiss-Prot
    Q8BPA9, Q8R1P4, Q9D3J7
    UniProtKB/TrEMBL
    A0A0R4J029
    Related
    ENSMUSP00000022119.5, ENSMUST00000022119.6
    Conserved Domains (1) summary
    pfam03987
    Location:95162
    Autophagy_act_C; Autophagocytosis associated protein, active-site domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    91083467..91372189 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244552.4XP_011242854.1  ubiquitin-like-conjugating enzyme ATG10 isoform X3

    Conserved Domains (1) summary
    pfam03987
    Location:54121
    Autophagy_act_C; Autophagocytosis associated protein, active-site domain

RNA

  1. XR_873450.4 RNA Sequence