Alg14 asparagine-linked glycosylation 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Alg14provided by MGI
Official Full Name: asparagine-linked glycosylation 14provided by MGI
Primary source: MGI:MGI:1914039
See related: Ensembl:ENSMUSG00000039887 AllianceGenome:MGI:1914039
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5430428G01Rik
Summary: Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to be located in endoplasmic reticulum; membrane; and nucleus. Predicted to be integral component of membrane. Predicted to be part of UDP-N-acetylglucosamine transferase complex. Is expressed in several structures, including early conceptus; gallbladder; genitourinary system; gut gland; and nervous system. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 15. Orthologous to human ALG14 (ALG14 UDP-N-acetylglucosaminyltransferase subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in lung adult (RPKM 8.4), subcutaneous fat pad adult (RPKM 8.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3; 3 G1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (121085361..121156745)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (121291712..121363096)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Alg14 gene: The Alg14 gene is conserved in human, chimpanzee, Rhesus monkey, dog, rat, chicken, zebrafish, fruit fly, mosquito, S.pombe, A.thaliana, and frog.
Orthologs from Annotation Pipeline: 474 organisms have orthologs with human gene Alg14
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
involved_in dolichol-linked oligosaccharide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
part_of UDP-N-acetylglucosamine transferase complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: UDP-N-acetylglucosamine transferase subunit ALG14 homolog

Names: asparagine-linked glycosylation 14 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024178.3 → NP_077140.1 UDP-N-acetylglucosamine transferase subunit ALG14 homolog

See identical proteins and their annotated locations for NP_077140.1

Status: VALIDATED

Source sequence(s)

AC105336, AC161210

Consensus CDS

CCDS17801.1

UniProtKB/Swiss-Prot

Q8CEP2, Q9D081

Related

ENSMUSP00000038387.8, ENSMUST00000039442.12

Conserved Domains (1) summary

pfam08660
Location:39 → 216

Alg14; Oligosaccharide biosynthesis protein Alg14 like

RNA

NR_155539.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC105336, AC161210

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

121085361..121156745

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501899.3 → XP_006501962.1 UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform X1

Conserved Domains (1) summary

pfam08660
Location:39 → 221

Alg14; Oligosaccharide biosynthesis protein Alg14 like