U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gskip GSK3B interacting protein [ Mus musculus (house mouse) ]

Gene ID: 66787, updated on 21-Apr-2024

Summary

Official Symbol
Gskipprovided by MGI
Official Full Name
GSK3B interacting proteinprovided by MGI
Primary source
MGI:MGI:1914037
See related
Ensembl:ENSMUSG00000044715 AllianceGenome:MGI:1914037
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933433P14Rik
Summary
Predicted to enable protein kinase A regulatory subunit binding activity; protein kinase binding activity; and protein kinase inhibitor activity. Predicted to be involved in intrinsic apoptotic signaling pathway in response to oxidative stress; negative regulation of protein kinase activity; and positive regulation of canonical Wnt signaling pathway. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including gut; liver; metanephros; spleen; and testis. Orthologous to human GSKIP (GSK3B interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 14.1), large intestine adult (RPKM 7.3) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
12 E; 12 55.92 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (105651611..105669317)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (105685352..105703058)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene bradykinin receptor, beta 1 Neighboring gene autophagy related 2B Neighboring gene STARR-seq mESC enhancer starr_33186 Neighboring gene STARR-seq mESC enhancer starr_33187 Neighboring gene STARR-positive B cell enhancer ABC_E5352 Neighboring gene adenylate kinase 7 Neighboring gene STARR-seq mESC enhancer starr_33192 Neighboring gene STARR-seq mESC enhancer starr_33193 Neighboring gene STARR-seq mESC enhancer starr_33194 Neighboring gene poly (A) polymerase alpha

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ20789

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase A binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase A binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase A regulatory subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
GSK3B-interacting protein
Names
GSK3-beta interaction protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178613.3NP_848728.2  GSK3B-interacting protein

    See identical proteins and their annotated locations for NP_848728.2

    Status: VALIDATED

    Source sequence(s)
    AC158526, AK017049
    Consensus CDS
    CCDS49161.1
    UniProtKB/Swiss-Prot
    Q8BGR8, Q8CDW3, Q8K2G9
    UniProtKB/TrEMBL
    Q3TBR1
    Related
    ENSMUSP00000057939.6, ENSMUST00000051934.7
    Conserved Domains (1) summary
    pfam05303
    Location:38138
    DUF727; Protein of unknown function (DUF727)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    105651611..105669317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)