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Piezo2 piezo-type mechanosensitive ion channel component 2 [ Mus musculus (house mouse) ]

Gene ID: 667742, updated on 9-Jul-2024

Summary

Official Symbol
Piezo2provided by MGI
Official Full Name
piezo-type mechanosensitive ion channel component 2provided by MGI
Primary source
MGI:MGI:1918781
See related
Ensembl:ENSMUSG00000041482 AllianceGenome:MGI:1918781
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam38b; Fam38b2; 5930434P17; 9030411M15Rik; 9430028L06Rik
Summary
Enables mechanosensitive cation channel activity. Involved in detection of mechanical stimulus involved in sensory perception. Acts upstream of or within cation transport and regulation of membrane potential. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in dorsal root ganglion and lung. Human ortholog(s) of this gene implicated in distal arthrogryposis type 3 and distal arthrogryposis type 5. Orthologous to human PIEZO2 (piezo type mechanosensitive ion channel component 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 12.4), lung adult (RPKM 5.9) and 9 other tissues See more
Orthologs
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Genomic context

See Piezo2 in Genome Data Viewer
Location:
18 E1; 18 35.95 cM
Exon count:
56
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (63143284..63520787, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (63010213..63387716, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene adenomatosis polyposis coli down-regulated 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:63137389-63137586 Neighboring gene N-ethylmaleimide sensitive fusion protein attachment protein gamma Neighboring gene STARR-seq mESC enhancer starr_44784 Neighboring gene predicted gene, 36651 Neighboring gene STARR-seq mESC enhancer starr_44785 Neighboring gene STARR-seq mESC enhancer starr_44786 Neighboring gene STARR-seq mESC enhancer starr_44787 Neighboring gene STARR-seq mESC enhancer starr_44788 Neighboring gene predicted gene, 26972 Neighboring gene STARR-seq mESC enhancer starr_44790 Neighboring gene predicted gene, 23581

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 
  • Targeted (5)  1 citation

General gene information

Markers

Clone Names

  • FLJ23403, MGC182702

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mechanosensitive monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mechanosensitive monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables monoatomic cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables monoatomic cation channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
piezo-type mechanosensitive ion channel component 2
Names
family with sequence similarity 38, member B
family with sequence similarity 38, member B2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039485.5NP_001034574.4  piezo-type mechanosensitive ion channel component 2

    Status: VALIDATED

    Source sequence(s)
    AC124391, AC132378, AC140554, AC162804
    Consensus CDS
    CCDS29296.2
    UniProtKB/Swiss-Prot
    E2JF23, Q8BSM4, Q8CD54, Q9D341
    UniProtKB/TrEMBL
    E9QNW4
    Related
    ENSMUSP00000040019.6, ENSMUST00000047480.13
    Conserved Domains (2) summary
    pfam12166
    Location:24122821
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:13831614
    PIEZO; Piezo

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    63143284..63520787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526169.4XP_006526232.1  piezo-type mechanosensitive ion channel component 2 isoform X4

    UniProtKB/Swiss-Prot
    E2JF23, Q8BSM4, Q8CD54, Q9D341
    Conserved Domains (2) summary
    pfam12166
    Location:24172826
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:13551622
    PIEZO; Piezo
  2. XM_006526168.4XP_006526231.1  piezo-type mechanosensitive ion channel component 2 isoform X3

    UniProtKB/Swiss-Prot
    E2JF23, Q8BSM4, Q8CD54, Q9D341
    Conserved Domains (2) summary
    pfam12166
    Location:24182827
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:13561623
    PIEZO; Piezo
  3. XM_006526173.4XP_006526236.1  piezo-type mechanosensitive ion channel component 2 isoform X7

    UniProtKB/TrEMBL
    A0A494B9V6, S4R2S0
    Related
    ENSMUSP00000138758.3, ENSMUST00000183217.9
    Conserved Domains (2) summary
    pfam12166
    Location:23412750
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:13681602
    PIEZO; Piezo
  4. XM_006526167.4XP_006526230.1  piezo-type mechanosensitive ion channel component 2 isoform X2

    UniProtKB/Swiss-Prot
    E2JF23, Q8BSM4, Q8CD54, Q9D341
    Conserved Domains (2) summary
    pfam12166
    Location:24302839
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:13681635
    PIEZO; Piezo
  5. XM_036161249.1XP_036017142.1  piezo-type mechanosensitive ion channel component 2 isoform X8

    UniProtKB/Swiss-Prot
    E2JF23, Q8BSM4, Q8CD54, Q9D341
    UniProtKB/TrEMBL
    A0A2H4UKA3
    Conserved Domains (2) summary
    pfam12166
    Location:24552864
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:13931660
    PIEZO; Piezo
  6. XM_006526170.4XP_006526233.1  piezo-type mechanosensitive ion channel component 2 isoform X5

    UniProtKB/Swiss-Prot
    E2JF23, Q8BSM4, Q8CD54, Q9D341
    Conserved Domains (2) summary
    pfam12166
    Location:23982807
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:13691603
    PIEZO; Piezo
  7. XM_006526172.4XP_006526235.1  piezo-type mechanosensitive ion channel component 2 isoform X6

    UniProtKB/TrEMBL
    A0A494B9V6
    Conserved Domains (2) summary
    pfam12166
    Location:23752784
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:13691636
    PIEZO; Piezo
  8. XM_006526166.4XP_006526229.1  piezo-type mechanosensitive ion channel component 2 isoform X1

    UniProtKB/Swiss-Prot
    E2JF23, Q8BSM4, Q8CD54, Q9D341
    Conserved Domains (2) summary
    pfam12166
    Location:24312840
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:13691636
    PIEZO; Piezo

RNA

  1. XR_386006.4 RNA Sequence

  2. XR_001782388.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172629.1: Suppressed sequence

    Description
    NM_172629.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.