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UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 [ Homo sapiens (human) ]

Gene ID: 6675, updated on 4-Dec-2022

Summary

Official Symbol
UAP1provided by HGNC
Official Full Name
UDP-N-acetylglucosamine pyrophosphorylase 1provided by HGNC
Primary source
HGNC:HGNC:12457
See related
Ensembl:ENSG00000117143 MIM:602862; AllianceGenome:HGNC:12457
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AGX; AGX1; AGX2; SPAG2
Summary
Enables identical protein binding activity. Predicted to be involved in UDP-N-acetylglucosamine biosynthetic process. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 52.4), liver (RPKM 41.2) and 25 other tissues See more
Orthologs
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Genomic context

See UAP1 in Genome Data Viewer
Location:
1q23.3
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (162561531..162601240)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (161905541..161945257)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (162531321..162571030)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene 2 Neighboring gene UAP1 divergent transcript Neighboring gene discoidin domain receptor tyrosine kinase 2 Neighboring gene Sharpr-MPRA regulatory region 4859 Neighboring gene RNA, 7SL, cytoplasmic 861, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of UDP-N-acteylglucosamine pyrophosphorylase 1 (UAP1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables UDP-N-acetylgalactosamine diphosphorylase activity IEA
Inferred from Electronic Annotation
more info
 
enables UDP-N-acetylglucosamine diphosphorylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in UDP-N-acetylglucosamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in UDP-N-acetylglucosamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
UDP-N-acetylhexosamine pyrophosphorylase
Names
UDP-N-acetylglucosamine diphosphorylase 1
UDP-N-acetylhexosamine pyrophosphorylase 1
antigen X
sperm associated antigen 2
testis tissue sperm-binding protein Li 37a
NP_001311042.1
NP_001311043.1
NP_001311044.1
NP_001311045.1
NP_001311046.1
NP_001375330.1
NP_001375331.1
NP_001386719.1
NP_001386720.1
NP_001386721.1
NP_001386722.1
NP_003106.3
XP_047284799.1
XP_047284801.1
XP_047284804.1
XP_047284805.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324113.2NP_001311042.1  UDP-N-acetylhexosamine pyrophosphorylase isoform a

    Status: VALIDATED

    Source sequence(s)
    AL596325
    Consensus CDS
    CCDS1240.1
    UniProtKB/Swiss-Prot
    Q16222
    UniProtKB/TrEMBL
    A0A140VKC0
    Conserved Domains (1) summary
    cd04193
    Location:88410
    UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc
  2. NM_001324114.2NP_001311043.1  UDP-N-acetylhexosamine pyrophosphorylase isoform a

    Status: VALIDATED

    Source sequence(s)
    AL596325
    Consensus CDS
    CCDS1240.1
    UniProtKB/Swiss-Prot
    Q16222
    UniProtKB/TrEMBL
    A0A140VKC0
    Conserved Domains (1) summary
    cd04193
    Location:88410
    UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc
  3. NM_001324115.3NP_001311044.1  UDP-N-acetylhexosamine pyrophosphorylase isoform a

    Status: VALIDATED

    Source sequence(s)
    AL596325
    Consensus CDS
    CCDS1240.1
    UniProtKB/Swiss-Prot
    Q16222
    UniProtKB/TrEMBL
    A0A140VKC0
    Conserved Domains (1) summary
    cd04193
    Location:88410
    UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc
  4. NM_001324116.5NP_001311045.1  UDP-N-acetylhexosamine pyrophosphorylase isoform b

    Status: VALIDATED

    Source sequence(s)
    AL596325
    Consensus CDS
    CCDS81393.1
    UniProtKB/Swiss-Prot
    Q16222, Q96GM2
    Related
    ENSP00000356902.1, ENST00000367925.6
    Conserved Domains (1) summary
    cd04193
    Location:88410
    UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc
  5. NM_001324117.3NP_001311046.1  UDP-N-acetylhexosamine pyrophosphorylase isoform c

    Status: VALIDATED

    Source sequence(s)
    AL596325
    UniProtKB/Swiss-Prot
    Q16222
    Conserved Domains (1) summary
    cd04193
    Location:88410
    UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc
  6. NM_001388401.1NP_001375330.1  UDP-N-acetylhexosamine pyrophosphorylase isoform b

    Status: VALIDATED

    Source sequence(s)
    AL596325
    Consensus CDS
    CCDS81393.1
    UniProtKB/Swiss-Prot
    Q96GM2
    Conserved Domains (1) summary
    cd04193
    Location:88410
    UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc
  7. NM_001388402.1NP_001375331.1  UDP-N-acetylhexosamine pyrophosphorylase isoform b

    Status: VALIDATED

    Source sequence(s)
    AL596325
    Consensus CDS
    CCDS81393.1
    UniProtKB/Swiss-Prot
    Q96GM2
    Conserved Domains (1) summary
    cd04193
    Location:88410
    UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc
  8. NM_001399790.1NP_001386719.1  UDP-N-acetylhexosamine pyrophosphorylase isoform a

    Status: VALIDATED

    Source sequence(s)
    AL596325
    Consensus CDS
    CCDS1240.1
    UniProtKB/TrEMBL
    A0A140VKC0
  9. NM_001399791.1NP_001386720.1  UDP-N-acetylhexosamine pyrophosphorylase isoform b

    Status: VALIDATED

    Source sequence(s)
    AL596325
    Consensus CDS
    CCDS81393.1
    UniProtKB/Swiss-Prot
    Q96GM2
  10. NM_001399792.1NP_001386721.1  UDP-N-acetylhexosamine pyrophosphorylase isoform d

    Status: VALIDATED

    Source sequence(s)
    AL596325
  11. NM_001399793.1NP_001386722.1  UDP-N-acetylhexosamine pyrophosphorylase isoform e

    Status: VALIDATED

    Source sequence(s)
    AL596325
  12. NM_003115.6NP_003106.3  UDP-N-acetylhexosamine pyrophosphorylase isoform a

    See identical proteins and their annotated locations for NP_003106.3

    Status: VALIDATED

    Source sequence(s)
    AL596325
    Consensus CDS
    CCDS1240.1
    UniProtKB/Swiss-Prot
    Q16222
    UniProtKB/TrEMBL
    A0A140VKC0
    Related
    ENSP00000356903.4, ENST00000367926.9
    Conserved Domains (1) summary
    cd04193
    Location:88410
    UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc

RNA

  1. NR_174352.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL596325

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    162561531..162601240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428845.1XP_047284801.1  UDP-N-acetylhexosamine pyrophosphorylase isoform X2

  2. XM_047428848.1XP_047284804.1  UDP-N-acetylhexosamine pyrophosphorylase isoform X2

  3. XM_047428843.1XP_047284799.1  UDP-N-acetylhexosamine pyrophosphorylase isoform X1

    UniProtKB/Swiss-Prot
    Q96GM2
  4. XM_047428849.1XP_047284805.1  UDP-N-acetylhexosamine pyrophosphorylase isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    161905541..161945257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)