Ifit3b interferon-induced protein with tetratricopeptide repeats 3B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ifit3bprovided by MGI
Official Full Name: interferon-induced protein with tetratricopeptide repeats 3Bprovided by MGI
Primary source: MGI:MGI:3698419
See related: Ensembl:ENSMUSG00000062488 AllianceGenome:MGI:3698419
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: I830012O16Rik
Summary: Predicted to enable RNA binding activity and identical protein binding activity. Predicted to be involved in defense response to virus; negative regulation of apoptotic process; and negative regulation of cell population proliferation. Predicted to be located in mitochondrion. Predicted to be active in cytosol. Orthologous to human IFIT3 (interferon induced protein with tetratricopeptide repeats 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 6.3), liver E18 (RPKM 4.8) and 18 other tissues See more
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Genomic context

Location:: 19; 19 C1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (34584945..34590801)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (34607530..34613403)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Ifit3b gene: The Ifit3b gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and rat.
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interferon-induced protein with tetratricopeptide repeats 3-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005858.3 → NP_001005858.2 interferon-induced protein with tetratricopeptide repeats 3-like

Status: VALIDATED

Source sequence(s)

AC016791, AK077243, CA576017

Consensus CDS

CCDS50423.1

UniProtKB/TrEMBL

E9PV48, Q8BPC3

Related

ENSMUSP00000075599.6, ENSMUST00000076249.6

Conserved Domains (3) summary

COG5010
Location:136 → 272

TadD; Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures]

sd00006
Location:136 → 164

TPR; TPR repeat [structural motif]

pfam13424
Location:48 → 126

TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

34584945..34590801

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527264.5 → XP_006527327.1 interferon-induced protein with tetratricopeptide repeats 3-like isoform X1

Conserved Domains (2) summary

TIGR02917
Location:81 → 325

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:161 → 189

TPR; TPR repeat [structural motif]