Emc2 ER membrane protein complex subunit 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Emc2provided by MGI
Official Full Name: ER membrane protein complex subunit 2provided by MGI
Primary source: MGI:MGI:1913986
See related: Ensembl:ENSMUSG00000022337 AllianceGenome:MGI:1913986
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ttc35; 4921531G14Rik
Summary: Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Located in mitochondrion. Orthologous to human EMC2 (ER membrane protein complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 27.1), cerebellum adult (RPKM 21.2) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15; 15 B3.2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (43340603..43391174)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (43477229..43527777)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW209495 (e-PCR)
- UniSTS:180754

NoName (e-PCR)
- UniSTS:237156

AV060620 (e-PCR)
- UniSTS:164576

Homology

Homologs of the Emc2 gene: The Emc2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 493 organisms have orthologs with human gene Emc2
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to membrane insertase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	ISO Inferred from Sequence Orthology more info
involved_in tail-anchored membrane protein insertion into ER membrane	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of EMC complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of EMC complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in extrinsic component of endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: ER membrane protein complex subunit 2

Names: TPR repeat protein 35; tetratricopeptide repeat domain 35; tetratricopeptide repeat protein 35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418323.1 → NP_001405252.1 ER membrane protein complex subunit 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC099614, AC099621
NM_001418325.1 → NP_001405254.1 ER membrane protein complex subunit 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC099614, AC099621
NM_001418326.1 → NP_001405255.1 ER membrane protein complex subunit 2 isoform 4

Status: VALIDATED

Source sequence(s)

AC099614, AC099621
NM_025736.3 → NP_080012.1 ER membrane protein complex subunit 2 isoform 1

See identical proteins and their annotated locations for NP_080012.1

Status: VALIDATED

Source sequence(s)

AC099614, AC099621

Consensus CDS

CCDS27453.1

UniProtKB/Swiss-Prot

Q925K1, Q9CRD2

UniProtKB/TrEMBL

Q6A0D1

Related

ENSMUSP00000022962.7, ENSMUST00000022962.8

Conserved Domains (4) summary

sd00006
Location:120 → 150

TPR; TPR repeat [structural motif]

pfam13414
Location:156 → 222

TPR_11; TPR repeat

pfam13432
Location:62 → 121

TPR_16; Tetratricopeptide repeat

pfam14559
Location:99 → 164

TPR_19; Tetratricopeptide repeat