U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Kcng4 potassium voltage-gated channel, subfamily G, member 4 [ Mus musculus (house mouse) ]

Gene ID: 66733, updated on 1-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
Kcng4provided by MGI
Official Full Name
potassium voltage-gated channel, subfamily G, member 4provided by MGI
Primary source
MGI:MGI:1913983
See related
Ensembl:ENSMUSG00000045246 AllianceGenome:MGI:1913983
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KV6.3; KV6.4; 4921535I01Rik
Summary
Predicted to enable delayed rectifier potassium channel activity and transmembrane transporter binding activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to act upstream of or within potassium ion transport and regulation of ion transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be integral component of membrane. Is expressed in central nervous system; gut; male reproductive gland or organ; and retina inner nuclear layer. Orthologous to human KCNG4 (potassium voltage-gated channel modifier subfamily G member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 22.8), testis adult (RPKM 5.9) and 6 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Kcng4 in Genome Data Viewer
Location:
8 E1; 8 68.07 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (120350593..120362497, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (119623854..119635680, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1772 Neighboring gene ribosomal protein S13, pseudogene 4 Neighboring gene TATA-box binding protein associated factor, RNA polymerase I, C Neighboring gene STARR-seq mESC enhancer starr_22857 Neighboring gene adenosine deaminase domain containing 2 Neighboring gene predicted gene, 46055 Neighboring gene predicted gene, 46054 Neighboring gene predicted gene, 32352 Neighboring gene WAP four-disulfide core domain 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Targeted deletion of the Kv6.4 subunit causes male sterility due to disturbed spermiogenesis. Regnier G, et al. Reprod Fertil Dev, 2017 Aug. PMID 27677211
  2. Gap junctional coupling between retinal amacrine and ganglion cells underlies coherent activity integral to global object perception. Roy K, et al. Proc Natl Acad Sci U S A, 2017 Nov 28. PMID 29133423, Free PMC Article
  3. Four alpha ganglion cell types in mouse retina: Function, structure, and molecular signatures. Krieger B, et al. PLoS One, 2017. PMID 28753612, Free PMC Article
  4. Elevated Pressure Increases Ca(2+) Influx Through AMPA Receptors in Select Populations of Retinal Ganglion Cells. Wen X, et al. Front Cell Neurosci, 2018. PMID 29950974, Free PMC Article
  5. The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration. Cartoni R, et al. Neuron, 2016 Dec 21. PMID 28009275, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables delayed rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transmembrane transporter binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
potassium voltage-gated channel subfamily G member 4
Names
voltage-gated potassium channel subunit Kv6.3
voltage-gated potassium channel subunit Kv6.4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357210.1 → NP_001344139.1  potassium voltage-gated channel subfamily G member 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC104882
    Conserved Domains (1) summary
    cl38908
    Location:58 → 167
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  2. NM_025734.2 → NP_080010.2  potassium voltage-gated channel subfamily G member 4 isoform 1

    See identical proteins and their annotated locations for NP_080010.2

    Status: VALIDATED

    Source sequence(s)
    BC043936
    Consensus CDS
    CCDS22710.1
    UniProtKB/Swiss-Prot
    Q80XM3
    Related
    ENSMUSP00000056552.4, ENSMUST00000061828.10
    Conserved Domains (2) summary
    cl38908
    Location:58 → 167
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:219 → 463
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    120350593..120362497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154242.1 → XP_036010135.1  potassium voltage-gated channel subfamily G member 4 isoform X3

    Conserved Domains (1) summary
    cl38908
    Location:58 → 167
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  2. XM_006531289.5 → XP_006531352.1  potassium voltage-gated channel subfamily G member 4 isoform X1

    See identical proteins and their annotated locations for XP_006531352.1

    UniProtKB/Swiss-Prot
    Q80XM3
    Conserved Domains (2) summary
    cl38908
    Location:58 → 167
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:219 → 463
    Ion_trans; Ion transport protein

  3. XM_036154241.1 → XP_036010134.1  potassium voltage-gated channel subfamily G member 4 isoform X2

    Conserved Domains (1) summary
    cl38908
    Location:58 → 167
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80XM3.1 GenPept UniProtKB/Swiss-Prot:Q80XM3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous