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Klhl10 kelch-like 10 [ Mus musculus (house mouse) ]

Gene ID: 66720, updated on 12-Mar-2023

Summary

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Official Symbol
Klhl10provided by MGI
Official Full Name
kelch-like 10provided by MGI
Primary source
MGI:MGI:2181067
See related
Ensembl:ENSMUSG00000001558 AllianceGenome:MGI:2181067
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4921517C11Rik
Summary
Acts upstream of or within several processes, including homeostasis of number of cells within a tissue; male sex differentiation; and spermatid development. Located in cytoplasm. Is expressed in alimentary system and male reproductive gland or organ. Human ortholog(s) of this gene implicated in spermatogenic failure 11. Orthologous to human KLHL10 (kelch like family member 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 56.4), cerebellum adult (RPKM 6.9) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Klhl10 in Genome Data Viewer
Location:
11; 11 D
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100331954..100347850)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100441128..100457027)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene prolyl 3-hydroxylase family member 4 (non-enzymatic) Neighboring gene FK506 binding protein 10 Neighboring gene 5'-nucleotidase, cytosolic IIIB Neighboring gene kelch-like 11 Neighboring gene microRNA 7116 Neighboring gene ATP citrate lyase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The I510V mutation in KLHL10 in a patient with oligoasthenoteratozoospermia. Huang Z, et al. J Reprod Dev, 2021 Oct 29. PMID 34433733, Free PMC Article
  2. Cullin3 is a KLHL10-interacting protein preferentially expressed during late spermiogenesis. Wang S, et al. Biol Reprod, 2006 Jan. PMID 16162871
  3. Haploinsufficiency of kelch-like protein homolog 10 causes infertility in male mice. Yan W, et al. Proc Natl Acad Sci U S A, 2004 May 18. PMID 15136734, Free PMC Article
  4. Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics. Lamberti A, et al. Biochimie, 2011 Oct. PMID 21689717
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (15) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The I510V mutation in KLHL10 in a patient with oligoasthenoteratozoospermia.
    Title: The I510V mutation in KLHL10 in a patient with oligoasthenoteratozoospermia.
  2. Both alleles are required for male fertility and haploinsufficiency prevents genetic transmission of both mutant and WT alleles.
    Title: Haploinsufficiency of kelch-like protein homolog 10 causes infertility in male mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within homeostasis of number of cells within a tissue IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within male genitalia morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within male gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
kelch-like protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417855.1 → NP_001404784.1  kelch-like protein 10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL590968

  2. NM_001417856.1 → NP_001404785.1  kelch-like protein 10 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL590968

  3. NM_025727.4 → NP_080003.1  kelch-like protein 10 isoform 1

    See identical proteins and their annotated locations for NP_080003.1

    Status: VALIDATED

    Source sequence(s)
    AL590968
    Consensus CDS
    CCDS25423.1
    UniProtKB/Swiss-Prot
    Q9D5V2, Q9DA07
    UniProtKB/TrEMBL
    A0A6P5QU40, A2A4I4, B2RTD7
    Related
    ENSMUSP00000001599.4, ENSMUST00000001599.4
    Conserved Domains (2) summary
    PHA03098
    Location:36 → 572
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:329 → 372
    Kelch; KELCH repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    100331954..100347850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314711.2 → XP_017170200.1  kelch-like protein 10 isoform X2

    Conserved Domains (3) summary
    smart00612
    Location:60 → 106
    Kelch; Kelch domain
    PHA03098
    Location:100 → 339
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:96 → 139
    Kelch; KELCH repeat [structural motif]

  2. XM_011249181.4 → XP_011247483.1  kelch-like protein 10 isoform X1

    Conserved Domains (3) summary
    smart00612
    Location:101 → 147
    Kelch; Kelch domain
    PHA03098
    Location:141 → 380
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:137 → 180
    Kelch; KELCH repeat [structural motif]

  3. XM_011249182.4 → XP_011247484.1  kelch-like protein 10 isoform X2

    Conserved Domains (3) summary
    smart00612
    Location:60 → 106
    Kelch; Kelch domain
    PHA03098
    Location:100 → 339
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:96 → 139
    Kelch; KELCH repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D5V2.1 GenPept UniProtKB/Swiss-Prot:Q9D5V2

Gene LinkOut

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