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Sbds SBDS ribosome maturation factor [ Mus musculus (house mouse) ]

Gene ID: 66711, updated on 26-Sep-2022

Summary

Official Symbol
Sbdsprovided by MGI
Official Full Name
SBDS ribosome maturation factorprovided by MGI
Primary source
MGI:MGI:1913961
See related
Ensembl:ENSMUSG00000025337 AllianceGenome:MGI:1913961
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SDS; CGI-97; 4733401P19Rik
Summary
This gene encodes a protein that is necessary for ribosome function and maintaining normal levels of protein synthesis. The encoded protein may function to activate ribosomes for translation, and may be involved in cellular response to stress and DNA damage. Loss of this gene is embryonic lethal while deficiency of the encoded protein in the pancreas is associated with symptoms of Shwachman-Diamond syndrome. [provided by RefSeq, Dec 2015]
Expression
Ubiquitous expression in bladder adult (RPKM 34.3), placenta adult (RPKM 26.8) and 28 other tissues See more
Orthologs
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Genomic context

See Sbds in Genome Data Viewer
Location:
5; 5 G1.3
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (130274573..130284371, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (130245732..130255530, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RAB guanine nucleotide exchange factor (GEF) 1 Neighboring gene predicted gene 15921 Neighboring gene transmembrane protein 248 Neighboring gene predicted gene 6598 Neighboring gene tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) Neighboring gene predicted gene, 40336 Neighboring gene calneuron 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables rRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in bone marrow development ISO
Inferred from Sequence Orthology
more info
 
involved_in bone mineralization ISO
Inferred from Sequence Orthology
more info
 
involved_in cytosolic ribosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inner cell mass cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leukocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
 
involved_in rRNA processing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ribosome maturation protein SBDS
Names
SBDS ribosome assembly guanine nucleotide exchange factor
Shwachman-Bodian-Diamond syndrome homolog
protein 22A3
shwachman-Bodian-Diamond syndrome protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023248.2NP_075737.1  ribosome maturation protein SBDS

    See identical proteins and their annotated locations for NP_075737.1

    Status: REVIEWED

    Source sequence(s)
    AI836084, AK014648, BY311303
    Consensus CDS
    CCDS19710.1
    UniProtKB/Swiss-Prot
    P70122, Q9CR18
    UniProtKB/TrEMBL
    A0A8C6HQX4
    Related
    ENSMUSP00000026387.5, ENSMUST00000026387.11
    Conserved Domains (3) summary
    COG1500
    Location:9241
    Sdo1; Ribosome maturation protein Sdo1 [Translation, ribosomal structure and biogenesis]
    pfam01172
    Location:1798
    SBDS; Shwachman-Bodian-Diamond syndrome (SBDS) protein
    pfam09377
    Location:107224
    SBDS_C; SBDS protein C-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    130274573..130284371 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504490.4XP_006504553.1  ribosome maturation protein SBDS isoform X1

    Conserved Domains (1) summary
    pfam09377
    Location:1119
    SBDS_C; SBDS protein C-terminal domain