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Ndufaf3 NADH:ubiquinone oxidoreductase complex assembly factor 3 [ Mus musculus (house mouse) ]

Gene ID: 66706, updated on 26-Sep-2022

Summary

Official Symbol
Ndufaf3provided by MGI
Official Full Name
NADH:ubiquinone oxidoreductase complex assembly factor 3provided by MGI
Primary source
MGI:MGI:1913956
See related
Ensembl:ENSMUSG00000070283 AllianceGenome:MGI:1913956
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4733401H18Rik
Summary
Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Is expressed in olfactory epithelium. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 18. Orthologous to human NDUFAF3 (NADH:ubiquinone oxidoreductase complex assembly factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 180.2), adrenal adult (RPKM 40.7) and 23 other tissues See more
Orthologs
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Genomic context

See Ndufaf3 in Genome Data Viewer
Location:
9; 9 F2
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108442786..108444635, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108565587..108567436, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene glutamine-rich 1 Neighboring gene inosine monophosphate dehydrogenase 2 Neighboring gene DALR anticodon binding domain containing 3 Neighboring gene microRNA 191 Neighboring gene microRNA 425

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in mitochondrial respiratory chain complex I assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3
Names
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3
nuclear protein E3-3
protein 2P1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023247.2NP_075736.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

    See identical proteins and their annotated locations for NP_075736.1

    Status: VALIDATED

    Source sequence(s)
    AF235017, AI837285, CT010508
    Consensus CDS
    CCDS23531.1
    UniProtKB/Swiss-Prot
    Q8K1A3, Q9JKL4
    UniProtKB/TrEMBL
    A0A8C6MNB1
    Related
    ENSMUSP00000073832.5, ENSMUST00000074208.6
    Conserved Domains (1) summary
    cd05125
    Location:59172
    Mth938_2P1-like; Mth938_2P1-like domain. This model contains sequences that are similar to 2P1, a partially characterized nuclear protein, which is homologous to E3-3 from rat and known to be alternatively spliced. Its function is unknown. This family is part of the ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    108442786..108444635 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)