Tbc1d15 TBC1 domain family, member 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tbc1d15provided by MGI
Official Full Name: TBC1 domain family, member 15provided by MGI
Primary source: MGI:MGI:1913937
See related: Ensembl:ENSMUSG00000020130 AllianceGenome:MGI:1913937
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ly6dl; Rab7-GAP; 4432405K22Rik
Summary: Enables GTPase activator activity. Involved in regulation of GTPase activity. Located in cytoplasm and extracellular region. Is expressed in brain; embryo; liver; spleen; and thymus. Orthologous to human TBC1D15 (TBC1 domain family member 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 15.0), bladder adult (RPKM 12.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10; 10 D2

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (115033776..115087401, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (115197871..115251493, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TBC1D15/RAB7-regulated mitochondria-lysosome interaction confers cardioprotection against acute myocardial infarction-induced cardiac injury.
Title: TBC1D15/RAB7-regulated mitochondria-lysosome interaction confers cardioprotection against acute myocardial infarction-induced cardiac injury.
nigericin-induced mitochondria fission was rescued by knockdown of either dynamin-related protein 1 or TBC1 domain family member 15 (TBC1D15), which are two distinct mitochondria fission regulators, only TBC1D15 restored the activity of the STING pathway, which indicates that inflammasome-activating signals curtail STING pathway activation via TBC1D15.
Title: Stimulator of IFN genes-mediated DNA-sensing pathway is suppressed by NLRP3 agonists and regulated by mitofusin 1 and TBC1D15, mitochondrial dynamics mediators.
identify TBC1D15 as a Numb-associated protein and demonstrate that its amino-terminal domain disengages p53 from Numb, triggering p53 proteolysis and promoting self-renewal and pluripotency
Title: The TBC1D15 oncoprotein controls stem cell self-renewal through destabilization of the Numb-p53 complex.
although only TBC1D15/Rab7-GAP altered Rab7-GTP levels, both Rab7-GAP and mVps39 regulate lysosomal morphology and play a role in maintaining growth factor dependence
Title: Differential effects of TBC1D15 and mammalian Vps39 on Rab7 activation state, lysosomal morphology, and growth factor dependence.
TBC1D15 may be involved in Rab7-mediated late endosomal trafficking
Title: TBC domain family, member 15 is a novel mammalian Rab GTPase-activating protein with substrate preference for Rab7.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU023730 (e-PCR)
- UniSTS:180119

NoName (e-PCR)
- UniSTS:234405

AU022358 (e-PCR)
- UniSTS:208607

AW557774 (e-PCR)
- UniSTS:185852

Homology

Homologs of the Tbc1d15 gene: The Tbc1d15 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog.
Orthologs from Annotation Pipeline: 479 organisms have orthologs with human gene Tbc1d15
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: TBC1 domain family member 15

Names: GAP for RAB7; GTPase-activating protein RAB7; lymphocyte antigen 6, locus D ligand

NP_079982.3

EC 1.15.1.1

XP_006514020.1

EC 1.15.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025706.3 → NP_079982.3 TBC1 domain family member 15

See identical proteins and their annotated locations for NP_079982.3

Status: VALIDATED

Source sequence(s)

AK147085, BB618866, BC053395, BY435567

Consensus CDS

CCDS24176.1

UniProtKB/Swiss-Prot

Q3UI41, Q9CXF4

UniProtKB/TrEMBL

Q7TPU5

Related

ENSMUSP00000020339.9, ENSMUST00000020339.10

Conserved Domains (2) summary

pfam12068
Location:8 → 224

DUF3548; Domain of unknown function (DUF3548)

smart00164
Location:326 → 561

TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

115033776..115087401 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513957.5 → XP_006514020.1 TBC1 domain family member 15 isoform X1

Conserved Domains (2) summary

smart00164
Location:343 → 578

TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

pfam12068
Location:10 → 211

DUF3548; Domain of unknown function (DUF3548)