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Tbc1d15 TBC1 domain family, member 15 [ Mus musculus (house mouse) ]

Gene ID: 66687, updated on 14-May-2024

Summary

Official Symbol
Tbc1d15provided by MGI
Official Full Name
TBC1 domain family, member 15provided by MGI
Primary source
MGI:MGI:1913937
See related
Ensembl:ENSMUSG00000020130 AllianceGenome:MGI:1913937
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ly6dl; Rab7-GAP; 4432405K22Rik
Summary
Enables GTPase activator activity. Involved in regulation of GTPase activity. Located in cytoplasm and extracellular region. Is expressed in brain; embryo; liver; spleen; and thymus. Orthologous to human TBC1D15 (TBC1 domain family member 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 15.0), bladder adult (RPKM 12.5) and 25 other tissues See more
Orthologs
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Genomic context

See Tbc1d15 in Genome Data Viewer
Location:
10 D2; 10 63.51 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (115031459..115087343, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (115197871..115251493, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27929 Neighboring gene predicted gene, 22070 Neighboring gene tryptophan hydroxylase 2 Neighboring gene STARR-seq mESC enhancer starr_27930 Neighboring gene STARR-seq mESC enhancer starr_27931 Neighboring gene STARR-seq mESC enhancer starr_27933 Neighboring gene STARR-positive B cell enhancer ABC_E3915 Neighboring gene predicted gene 8942 Neighboring gene STARR-positive B cell enhancer ABC_E3916 Neighboring gene RAB21, member RAS oncogene family

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
TBC1 domain family member 15
Names
GAP for RAB7
GTPase-activating protein RAB7
lymphocyte antigen 6, locus D ligand
NP_001414153.1
NP_001414154.1
NP_001414155.1
NP_079982.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427224.1NP_001414153.1  TBC1 domain family member 15 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC153825
  2. NM_001427225.1NP_001414154.1  TBC1 domain family member 15 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC153825
  3. NM_001427226.1NP_001414155.1  TBC1 domain family member 15 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC153825
  4. NM_001429383.1NP_001416312.1  TBC1 domain family member 15 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC153825
  5. NM_025706.4NP_079982.3  TBC1 domain family member 15 isoform 2

    See identical proteins and their annotated locations for NP_079982.3

    Status: VALIDATED

    Source sequence(s)
    AC153825
    Consensus CDS
    CCDS24176.1
    UniProtKB/Swiss-Prot
    Q3UI41, Q9CXF4
    UniProtKB/TrEMBL
    Q4TVN0
    Related
    ENSMUSP00000020339.9, ENSMUST00000020339.10
    Conserved Domains (2) summary
    pfam12068
    Location:8224
    DUF3548; Domain of unknown function (DUF3548)
    smart00164
    Location:326561
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    115031459..115087343 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)