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Ccnh cyclin H [ Mus musculus (house mouse) ]

Gene ID: 66671, updated on 9-Mar-2023

Summary

Official Symbol
Ccnhprovided by MGI
Official Full Name
cyclin Hprovided by MGI
Primary source
MGI:MGI:1913921
See related
Ensembl:ENSMUSG00000021548 AllianceGenome:MGI:1913921
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6330408H09Rik
Summary
Enables kinase activity. Predicted to be involved in several processes, including protein stabilization; regulation of cyclin-dependent protein serine/threonine kinase activity; and transcription initiation from RNA polymerase II promoter. Located in nucleus. Is expressed in cerebellum; cranium; and limb mesenchyme. Orthologous to human CCNH (cyclin H). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 14.7), CNS E18 (RPKM 11.2) and 26 other tissues See more
Orthologs
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Genomic context

See Ccnh in Genome Data Viewer
Location:
13; 13 C3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (85337504..85361850)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (85189377..85213731)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene smoothened homolog pseudogene Neighboring gene NADH-ubiquinone oxidoreductase chain 5-like Neighboring gene RAS p21 protein activator 1 Neighboring gene high mobility group box 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of CAK-ERCC2 complex ISO
Inferred from Sequence Orthology
more info
 
part_of cyclin-dependent protein kinase activating kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transcription factor TFIIH core complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription factor TFIIH holo complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription factor TFIIK complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transcription factor TFIIK complex ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347587.1NP_001334516.1  cyclin-H isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AK078059, BM899601, BQ032543, BY767531
    Consensus CDS
    CCDS84047.1
    UniProtKB/Swiss-Prot
    Q61458
    UniProtKB/TrEMBL
    E9PWD3
    Related
    ENSMUSP00000129349.2, ENSMUST00000163600.8
  2. NM_001347588.1NP_001334517.1  cyclin-H isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
    Source sequence(s)
    AK078059, BM899601, BY767531
    UniProtKB/Swiss-Prot
    Q61458
  3. NM_023243.6NP_075732.1  cyclin-H isoform a

    See identical proteins and their annotated locations for NP_075732.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK078059, BM899601, BY767531
    Consensus CDS
    CCDS26666.1
    UniProtKB/Swiss-Prot
    Q61458, Q9JHV7
    Related
    ENSMUSP00000022030.5, ENSMUST00000022030.11
    Conserved Domains (3) summary
    TIGR00569
    Location:2308
    ccl1; cyclin ccl1
    smart00385
    Location:62152
    CYCLIN; domain present in cyclins, TFIIB and Retinoblastoma
    pfam16899
    Location:162262
    Cyclin_C_2; Cyclin C-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    85337504..85361850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517325.4XP_006517388.1  cyclin-H isoform X1

    Conserved Domains (1) summary
    TIGR00569
    Location:2213
    ccl1; cyclin ccl1