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Atg4a autophagy related 4A, cysteine peptidase [ Mus musculus (house mouse) ]

Gene ID: 666468, updated on 5-Mar-2024

Summary

Official Symbol
Atg4aprovided by MGI
Official Full Name
autophagy related 4A, cysteine peptidaseprovided by MGI
Primary source
MGI:MGI:2147903
See related
Ensembl:ENSMUSG00000079418 AllianceGenome:MGI:2147903
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Apg4a; Autl2; Atg4al
Summary
Predicted to enable cysteine-type peptidase activity. Predicted to act upstream of or within proteolysis. Is expressed in embryo. Orthologous to human ATG4A (autophagy related 4A cysteine peptidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in genital fat pad adult (RPKM 11.0), placenta adult (RPKM 5.0) and 20 other tissues See more
Orthologs
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Genomic context

See Atg4a in Genome Data Viewer
Location:
X F1; X 61.67 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (139854594..139947190)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (140953845..141164194)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene ribosomal protein S7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_48010 Neighboring gene STARR-positive B cell enhancer ABC_E3263 Neighboring gene V-set and immunoglobulin domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_48011 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 Neighboring gene STARR-positive B cell enhancer mm9_chrX:137591358-137591658 Neighboring gene collagen, type IV, alpha 6 Neighboring gene predicted gene, 39539 Neighboring gene prohibitin pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Markers

Clone Names

  • MGC107179

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-phosphatidylethanolamide deconjugating activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-phosphatidylethanolamide deconjugating activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in C-terminal protein lipidation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in aggrephagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in mitophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein delipidation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein delipidation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
cysteine protease ATG4A
Names
APG4 (ATG4) autophagy-related homolog A
AUT-like 2, cysteine endopeptidase
autophagin 2
autophagy 4 homolog A
autophagy-related 4A
autophagy-related cysteine endopeptidase 2
autophagy-related protein 4 homolog A
cysteine protease APG4A
NP_001366610.1
NP_001366611.1
NP_001366612.1
NP_001366613.1
NP_777364.3
XP_017174089.1
XP_017174090.1
XP_017174091.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379681.1NP_001366610.1  cysteine protease ATG4A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL672306, AL691493, CR478060, CT025930
    UniProtKB/TrEMBL
    A0A0G2JFS9
    Conserved Domains (1) summary
    pfam03416
    Location:109399
    Peptidase_C54; Peptidase family C54
  2. NM_001379682.1NP_001366611.1  cysteine protease ATG4A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL672306, AL691493, CR478060, CT025930
    UniProtKB/TrEMBL
    A0A0G2JFS9
    Conserved Domains (1) summary
    pfam03416
    Location:42331
    Peptidase_C54; Peptidase family C54
  3. NM_001379683.1NP_001366612.1  cysteine protease ATG4A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL672306, AL691493, CR478060, CT025930
    UniProtKB/TrEMBL
    A0A0G2JFS9, A0A7N9VS64
    Related
    ENSMUSP00000159430.2, ENSMUST00000239541.1
    Conserved Domains (1) summary
    pfam03416
    Location:41308
    Peptidase_C54; Peptidase family C54
  4. NM_001379684.1NP_001366613.1  cysteine protease ATG4A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL672306, AL691493, CR478060, CT025930
    UniProtKB/TrEMBL
    A0A0G2JFS9
    Conserved Domains (1) summary
    pfam03416
    Location:1255
    Peptidase_C54; Peptidase family C54
  5. NM_174875.5NP_777364.3  cysteine protease ATG4A isoform 1

    See identical proteins and their annotated locations for NP_777364.3

    Status: VALIDATED

    Source sequence(s)
    AK041379, BB638045, BY287162, CJ057919, CO425906
    Consensus CDS
    CCDS85810.1
    UniProtKB/Swiss-Prot
    Q811B8, Q8C9S8
    UniProtKB/TrEMBL
    A0A0G2JFS9, Q5EBK1
    Related
    ENSMUSP00000108595.2, ENSMUST00000112971.2
    Conserved Domains (1) summary
    pfam03416
    Location:43332
    Peptidase_C54; Peptidase family C54

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    139854594..139947190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318600.2XP_017174089.1  cysteine protease ATG4A isoform X1

    UniProtKB/TrEMBL
    A0A0G2JFS9
    Conserved Domains (1) summary
    pfam03416
    Location:108375
    Peptidase_C54; Peptidase family C54
  2. XM_017318602.3XP_017174091.1  cysteine protease ATG4A isoform X2

    UniProtKB/TrEMBL
    A0A0G2JFS9
    Conserved Domains (1) summary
    pfam03416
    Location:38328
    Peptidase_C54; Peptidase family C54
  3. XM_017318601.3XP_017174090.1  cysteine protease ATG4A isoform X2

    UniProtKB/TrEMBL
    A0A0G2JFS9
    Conserved Domains (1) summary
    pfam03416
    Location:38328
    Peptidase_C54; Peptidase family C54

RNA

  1. XR_004940359.1 RNA Sequence

    Related
    ENSMUST00000239544.1